Associated Genetic Biomarkers
BRAF D594N is present in 0.11% of AACR GENIE cases, with melanoma, non-small cell lung carcinoma, bladder carcinoma, colorectal adenocarcinoma, and adenocarcinoma of unknown primary having the greatest prevalence .
BRAF D594N serves as an inclusion eligibility criterion in 2 clinical trials, of which 1 is open and 1 is closed. Of the trials that contain BRAF D594N as an inclusion criterion, 2 are phase 1 (1 open).
Trials with BRAF D594N in the inclusion eligibility criteria most commonly target malignant solid tumor and non-small cell lung carcinoma .
Rmc-4630 is the most frequent therapy in trials with BRAF D594N as an inclusion criteria .
Significance of BRAF D594N in Diseases
Malignant Solid Tumor +
BRAF is mutated in 39.82% of malignant solid tumor patients with BRAF D594N present in 1.1% of all malignant solid tumor patients .
BRAF D594N is an inclusion criterion in 2 clinical trials for malignant solid tumor, of which 1 is open and 1 is closed. Of the trials that contain BRAF D594N and malignant solid tumor as inclusion criteria, 2 are phase 1 (1 open) .
Rmc-4630 is the most frequent therapy in trials for malignant solid tumor that contain BRAF D594N .
Non-Small Cell Lung Carcinoma +
BRAF is mutated in 5.34% of non-small cell lung carcinoma patients with BRAF D594N present in 0.18% of all non-small cell lung carcinoma patients .
BRAF D594N is an inclusion criterion in 1 clinical trial for non-small cell lung carcinoma, of which 0 are open and 1 is closed. Of the trial that contains BRAF D594N and non-small cell lung carcinoma as inclusion criteria, 1 is phase 1 (0 open) .
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