Gene Location [1]
Receptor tyrosine kinase/growth factor signaling
Variant Type

EGFR Amplification is present in 2.09% of AACR GENIE cases, with malignant glioma, non-small cell lung carcinoma, breast carcinoma, colorectal adenocarcinoma, and head and neck squamous cell carcinoma having the greatest prevalence [4].

Top Disease Cases with EGFR Amplification

Significance of EGFR Amplification in Diseases

Malignant Solid Tumor +

Glioblastoma +

Breast Carcinoma +

Non-Small Cell Lung Carcinoma +

Glioma +

Squamous Cell Lung Carcinoma +

Non-Hodgkin Lymphoma +

Head And Neck Squamous Cell Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Gastric Carcinoma +

Urothelial Carcinoma +

Colorectal Carcinoma +

Pancreatic Carcinoma +

Cancer +

Endometrial Carcinoma +

Malignant Glioma +

Anaplastic Astrocytoma +

Esophageal Carcinoma +

Gliosarcoma +

Anaplastic Oligoastrocytoma +

Gastric Adenocarcinoma +

Nasal Cavity And Paranasal Sinus Carcinoma +

Meningioma +

Cholangiocarcinoma +

Hepatocellular Carcinoma +

Melanoma +

Prostate Carcinoma +

Renal Cell Carcinoma +

Anaplastic Oligodendroglioma +

B-Cell Non-Hodgkin Lymphoma +

Brain Metastasis +

Chordoma +

Gastrointestinal Stromal Tumor +

Hepatobiliary Neoplasm +

Histiocytic And Dendritic Cell Neoplasm +

Lip And Oral Cavity Carcinoma +

Malignant Brain Neoplasm +

Malignant Laryngeal Neoplasm +

Malignant Leptomeningeal Neoplasm +

Malignant Salivary Gland Neoplasm +

Medulloblastoma +

Multiple Myeloma +

Nasopharyngeal Carcinoma +

Oropharyngeal Carcinoma +

Ovarian Carcinoma +

Peritoneal Mesothelioma +

Pituitary Gland Neoplasm +

Thyroid Gland Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.