Gene Location [1]
Receptor tyrosine kinase/growth factor signaling
Variant Type

EGFR Amplification is present in 2.59% of AACR GENIE cases, with conventional glioblastoma multiforme, lung adenocarcinoma, glioblastoma, breast invasive ductal carcinoma, and colon adenocarcinoma having the greatest prevalence [4].

Top Disease Cases with EGFR Amplification

Significance of EGFR Amplification in Diseases

Glioblastoma +

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Gastric Carcinoma +

Squamous Cell Lung Carcinoma +

Breast Carcinoma +

Malignant Glioma +

Glioma +

Anaplastic Astrocytoma +

Gliosarcoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Diffuse Astrocytoma +

Colorectal Carcinoma +

Urothelial Carcinoma +

Pancreatic Carcinoma +

Chordoma +

Hypopharyngeal Squamous Cell Carcinoma +

Laryngeal Squamous Cell Carcinoma +

Malignant Laryngeal Neoplasm +

Glioblastoma, IDH-Wildtype +

Lip And Oral Cavity Carcinoma +

Oral Cavity Carcinoma +

Oral Cavity Squamous Cell Carcinoma +

Esophageal Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Lung Adenocarcinoma +

Anaplastic Oligoastrocytoma +

Gastric Adenocarcinoma +

Nasal Cavity And Paranasal Sinus Carcinoma +

Cancer +

Oropharyngeal Carcinoma +

Oropharyngeal Squamous Cell Carcinoma +

Hepatobiliary Neoplasm +

Malignant Hepatobiliary Neoplasm +

Cholangiocarcinoma +

Hepatocellular Carcinoma +

Meningioma +

Low Grade Glioma +

B-Cell Non-Hodgkin Lymphoma +

Malignant Salivary Gland Neoplasm +

Pancreatic Adenocarcinoma +

Ovarian Carcinoma +

Anal Canal Squamous Cell Carcinoma +

Anaplastic Oligodendroglioma +

Gastrointestinal Stromal Tumor +

Malignant Supratentorial Neoplasm +

Medulloblastoma +

Multiple Myeloma +

Nasopharyngeal Carcinoma +

Pituitary Gland Carcinoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

Uveal Melanoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.