Gene Location [1]
Receptor tyrosine kinase/growth factor signaling
Variant Type
Substitution - Missense

EGFR Codon 719 Missense is present in 0.26% of AACR GENIE cases, with lung adenocarcinoma, conventional glioblastoma multiforme, glioblastoma, non-small cell lung carcinoma, and poorly differentiated non-small cell lung cancer having the greatest prevalence [4].

Top Disease Cases with EGFR Codon 719 Missense

Biomarker-Directed Therapies

Significance of EGFR Codon 719 Missense in Diseases

Non-Small Cell Lung Carcinoma +

Lung Adenocarcinoma +

Malignant Solid Tumor +

Breast Carcinoma +

Melanoma +

Non-Squamous Non-Small Cell Lung Carcinoma +

Urothelial Carcinoma +

Bladder Carcinoma +

Colorectal Carcinoma +

Head And Neck Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Lung Carcinoma +

Glioblastoma +

Gallbladder Carcinoma +

Squamous Cell Lung Carcinoma +

Small Cell Lung Carcinoma +

WHO Grade III Glioma +

Gastric Adenocarcinoma +

Gastric Carcinoma +

Soft Tissue Sarcoma +

Adenocarcinoma Of The Gastroesophageal Junction +

B-Cell Non-Hodgkin Lymphoma +

Bile Duct Carcinoma +

Bronchogenic Carcinoma +

Cervical Carcinoma +

Cervical Squamous Cell Carcinoma +

Diffuse Midline Glioma, H3 K27M-Mutant +

Endometrial Carcinoma +

Esophageal Squamous Cell Carcinoma +

Hepatocellular Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Malignant Uterine Neoplasm +

Mesothelioma +

Multiple Myeloma +

Ovarian Carcinoma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Prostate Carcinoma +

Renal Cell Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.