Gene Location [1]
Receptor tyrosine kinase/growth factor signaling
Variant Type

Biomarker-Directed Therapies

Significance of EGFR Expression in Diseases

Colorectal Carcinoma +

Malignant Solid Tumor +

Gastric Carcinoma +

Breast Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Non-Small Cell Lung Carcinoma +

Chordoma +

Head And Neck Squamous Cell Carcinoma +

Hepatocellular Carcinoma +

Malignant Central Nervous System Neoplasm +

Pancreatic Carcinoma +

Anal Canal Squamous Cell Carcinoma +

Anal Carcinoma +

Cancer +

Cholangiocarcinoma +

Diffuse Intrinsic Pontine Glioma +

Esophageal Carcinoma +

Gastric Adenocarcinoma +

Glioblastoma +

Head And Neck Carcinoma +

Melanoma +

Ovarian Carcinoma +

Sarcoma +

Skin Squamous Cell Carcinoma +

Small Intestinal Carcinoma +

Squamous Cell Lung Carcinoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

Urothelial Carcinoma +

Uveal Melanoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.