Associated Genetic Biomarkers

Overview

NCI Definition: A primary or metastatic malignant neoplasm involving the brain or spinal cord. Representative examples include anaplastic astrocytoma, glioblastoma, anaplastic (malignant) meningioma, lymphoma, and metastatic carcinoma from another anatomic site. [1]

Malignant central nervous system neoplasms most frequently harbor alterations in TP53, IDH1, CDKN2A, PTEN, and CDKN2B [2].

Most Commonly Altered Genes in Malignant Central Nervous System Neoplasm

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, IDH1 Mutation, and IDH1 Codon 132 Missense are the most common alterations in malignant central nervous system neoplasm [2].

Top Alterations in Malignant Central Nervous System Neoplasm

Significant Genes in Malignant Central Nervous System Neoplasm

ALK +

ATM +

ATR +

BARD1 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

CDK12 +

CHEK1 +

CHEK2 +

ERBB2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

H3F3A +

MCPH1 +

MDM2 +

MDM4 +

MRE11A +

NBN +

PALB2 +

PPM1D +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RET +

ROS1 +

SLX4 +

SMARCA4 +

SMARCB1 +

TET2 +

Disease Details

Synonyms
Cancer of the CNS, Cancer of the Central Nervous System, Malignant CNS Tumor, Central Nervous System Cancer, Malignant Tumor of the Central Nervous System
Parent(s)
Malignant Nervous System Neoplasm
Children
Central Nervous System Lymphoma, Malignant Neoplasm of the Meninges, Malignant Intracranial Neoplasm, Malignant Glioma, Central Nervous System Embryonal Neoplasm, Glioma, Central Nervous System Sarcoma, Malignant Spinal Cord Neoplasm, Central Nervous System Leukemia, and Malignant Central Nervous System Germ Cell Tumor

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.