Overview

Gene Location [1]
10q26.13
Pathways
Receptor tyrosine kinase/growth factor signaling, Kinase fusions
Variant Type
Fusion
Gene
FGFR2

FGFR2 Fusion is present in 0.32% of AACR GENIE cases, with intrahepatic cholangiocarcinoma, breast invasive ductal carcinoma, cholangiocarcinoma, adenocarcinoma of unknown primary, and cancer of unknown primary having the greatest prevalence [4].

Top Disease Cases with FGFR2 Fusion

Biomarker-Directed Therapies

Significance of FGFR2 Fusion in Diseases

Cholangiocarcinoma +

Malignant Solid Tumor +

Urothelial Carcinoma +

Non-Small Cell Lung Carcinoma +

Intrahepatic Cholangiocarcinoma +

Gastric Carcinoma +

Cancer +

Multiple Myeloma +

Adenocarcinoma Of The Gastroesophageal Junction +

Breast Carcinoma +

Endometrial Carcinoma +

Squamous Cell Lung Carcinoma +

Bladder Carcinoma +

Pancreatic Carcinoma +

Colorectal Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Sarcoma +

Glioblastoma +

Anaplastic Astrocytoma +

Malignant Hepatobiliary Neoplasm +

Hepatobiliary Neoplasm +

Gastric Adenocarcinoma +

Extrahepatic Cholangiocarcinoma +

Esophageal Carcinoma +

Lip And Oral Cavity Carcinoma +

Pancreatic Adenocarcinoma +

Ovarian Carcinoma +

Small Cell Lung Carcinoma +

Malignant Salivary Gland Neoplasm +

Head And Neck Carcinoma +

Lymphocytic Neoplasm +

Anaplastic Oligodendroglioma +

B-Cell Non-Hodgkin Lymphoma +

Gastrointestinal Stromal Tumor +

Histiocytic And Dendritic Cell Neoplasm +

Lymphoma +

Malignant Laryngeal Neoplasm +

Melanoma +

Myeloid Neoplasm +

Myeloproliferative Neoplasm +

Nasal Cavity And Paranasal Sinus Carcinoma +

Nasopharyngeal Carcinoma +

Non-Hodgkin Lymphoma +

Non-Muscle Invasive Bladder Carcinoma +

Oropharyngeal Carcinoma +

Perihilar Intrahepatic Cholangiocarcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.