Associated Genetic Biomarkers

Overview

Gene Location [1]
13q12.2
Pathway
Receptor tyrosine kinase/growth factor signaling
Gene
FLT3

FLT3 Mutation is present in 1.73% of AACR GENIE cases, with acute myeloid leukemia, lung adenocarcinoma, cutaneous melanoma, colon adenocarcinoma, and melanoma having the greatest prevalence [4].

Top Disease Cases with FLT3 Mutation

Significance of FLT3 Mutation in Diseases

Acute Myeloid Leukemia +

Myelodysplastic Syndromes +

Acute Lymphoblastic Leukemia +

Malignant Solid Tumor +

Chronic Myelomonocytic Leukemia +

Chronic Myeloid Leukemia +

Multiple Myeloma +

B-Cell Acute Lymphoblastic Leukemia +

Non-Hodgkin Lymphoma +

Hodgkin Lymphoma +

Secondary Acute Myeloid Leukemia +

Acute Leukemia +

Melanoma +

Diffuse Large B-Cell Lymphoma +

Non-Small Cell Lung Carcinoma +

Bladder Carcinoma +

Colorectal Carcinoma +

Ovarian Carcinoma +

Breast Carcinoma +

Pancreatic Carcinoma +

Head And Neck Carcinoma +

Mantle Cell Lymphoma +

Mixed Phenotype Acute Leukemia +

T-Cell Lymphoblastic Leukemia/Lymphoma +

Therapy-Related Acute Myeloid Leukemia +

Therapy-Related Myelodysplastic Syndrome +

B-Cell Lymphoblastic Leukemia/Lymphoma +

Malignant Uterine Neoplasm +

Lymphoma +

Anaplastic Astrocytoma +

Glioblastoma +

Lung Carcinoma +

Cancer +

B-Cell Non-Hodgkin Lymphoma +

Cervical Carcinoma +

Esophageal Carcinoma +

Bile Duct Carcinoma +

Sarcoma +

Acute Biphenotypic Leukemia +

Acute Erythroid Leukemia +

Acute Megakaryoblastic Leukemia +

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome +

Acute Promyelocytic Leukemia +

Acute Undifferentiated Leukemia +

Adenocarcinoma Of The Gastroesophageal Junction +

Anaplastic Large Cell Lymphoma +

Aplastic Anemia +

B-Cell Prolymphocytic Leukemia +

Bronchogenic Carcinoma +

Burkitt Leukemia +

Burkitt Lymphoma +

Chronic Lymphocytic Leukemia +

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma +

Esophageal Squamous Cell Carcinoma +

Follicular Lymphoma +

Gallbladder Carcinoma +

Gastric Adenocarcinoma +

Lymphoblastic Lymphoma +

Marginal Zone Lymphoma +

Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable +

Myeloproliferative Neoplasm +

T-Cell Prolymphocytic Leukemia +

Therapy-Related Chronic Myelomonocytic Leukemia +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.