Overview

Biomarker-Directed Therapies

Significance of HER2 Negative in Diseases

Breast Carcinoma +

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Ovarian Carcinoma +

Colorectal Carcinoma +

Gastric Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Melanoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Breast Adenocarcinoma +

Pancreatic Carcinoma +

Renal Cell Carcinoma +

Fallopian Tube Carcinoma +

Primary Peritoneal Carcinoma +

Urothelial Carcinoma +

Gastric Adenocarcinoma +

Prostate Carcinoma +

Invasive Breast Carcinoma +

Small Cell Lung Carcinoma +

Endometrial Carcinoma +

Esophageal Carcinoma +

Bladder Carcinoma +

Hepatocellular Carcinoma +

Cervical Carcinoma +

Pancreatic Adenocarcinoma +

Head And Neck Carcinoma +

Lymphoma +

Soft Tissue Sarcoma +

Pancreatic Ductal Adenocarcinoma +

Glioblastoma +

Mesothelioma +

Squamous Cell Lung Carcinoma +

Breast Invasive Ductal Carcinoma +

Prostate Adenocarcinoma +

Colorectal Adenocarcinoma +

Ductal Carcinoma In Situ +

Nasopharyngeal Carcinoma +

Peritoneal Mesothelioma +

Sarcoma +

Cancer +

Chronic Lymphocytic Leukemia +

Diffuse Large B-Cell Lymphoma +

Esophageal Adenocarcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Inflammatory Breast Carcinoma +

Merkel Cell Carcinoma +

Multiple Myeloma +

Non-Hodgkin Lymphoma +

Acute Myeloid Leukemia +

Cholangiocarcinoma +

Clear Cell Renal Cell Carcinoma +

Esophageal Squamous Cell Carcinoma +

Esophagogastric Carcinoma +

Mantle Cell Lymphoma +

Pleural Mesothelioma +

Acute Lymphoblastic Leukemia +

Adenoid Cystic Carcinoma +

Carcinoma +

Cervical Squamous Cell Carcinoma +

Colon Carcinoma +

Fallopian Tube Endometrioid Adenocarcinoma +

Gastrointestinal Stromal Tumor +

High Grade Fallopian Tube Serous Adenocarcinoma +

Intrahepatic Cholangiocarcinoma +

Kidney Carcinoma +

Lobular Breast Carcinoma +

Malignant Ovarian Epithelial Tumor +

Malignant Pleural Mesothelioma +

Myelodysplastic Syndromes +

Neuroendocrine Carcinoma +

Thymic Carcinoma +

Thyroid Gland Carcinoma +

Urethral Carcinoma +

Anal Carcinoma +

Anal Squamous Cell Carcinoma +

Anaplastic Astrocytoma +

B-Cell Neoplasm +

B-Cell Non-Hodgkin Lymphoma +

Biliary Tract Carcinoma +

Breast Invasive Lobular Carcinoma +

Breast Lobular Carcinoma In Situ +

Central Nervous System Neoplasm +

Classical Hodgkin Lymphoma +

Cutaneous Melanoma +

Diffuse Gastric Adenocarcinoma +

Endometrial Adenocarcinoma +

Extrahepatic Cholangiocarcinoma +

Fallopian Tube Clear Cell Adenocarcinoma +

Gallbladder Carcinoma +

Germ Cell Tumor +

Hematopoietic And Lymphoid Malignancy +

Hypopharyngeal Carcinoma +

Laryngeal Carcinoma +

Leiomyosarcoma +

Lung Adenocarcinoma +

Lung Carcinoma +

Malignant Mixed Mesodermal (Mullerian) Tumor +

Malignant Ovarian Clear Cell Tumor +

Malignant Thyroid Gland Neoplasm +

Malignant Uterine Neoplasm +

NUT Midline Carcinoma Of The Head And Neck +

Oral Cavity Carcinoma +

Oropharyngeal Carcinoma +

Ovarian Endometrioid Adenocarcinoma +

Ovarian Endometrioid Tumor +

Ovarian Epithelial Tumor +

Pancreatic Neuroendocrine Neoplasm +

Papillary Renal Cell Carcinoma +

Primary Peritoneal Serous Adenocarcinoma +

Prostate Undifferentiated Carcinoma +

Renal Pelvis Carcinoma +

Renal Pelvis And Ureter Carcinoma +

Skin Squamous Cell Carcinoma +

Small Intestinal Adenocarcinoma +

T-Cell And NK-Cell Neoplasm +

Thymoma +

Thyroid Gland Follicular Carcinoma +

Transitional Cell Carcinoma +

Ureter Urothelial Carcinoma +

Well-Differentiated Thyroid Gland Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.