Overview

Gene Location [1]
8q24.21
Variant Type
Amplification
Gene
MYC

MYC Amplification is present in 3.56% of AACR GENIE cases, with breast carcinoma, non-small cell lung carcinoma, colorectal adenocarcinoma, prostate cancer, and ovarian neoplasm having the greatest prevalence [4].

Top Disease Cases with MYC Amplification

Significance of MYC Amplification in Diseases

Diffuse Large B-Cell Lymphoma +

Malignant Solid Tumor +

Follicular Lymphoma +

Hodgkin Lymphoma +

Mature B-Cell Lymphoma/Leukemia +

Non-Hodgkin Lymphoma +

Breast Carcinoma +

Mantle Cell Lymphoma +

Non-Small Cell Lung Carcinoma +

Burkitt Lymphoma +

Chronic Lymphocytic Leukemia +

Double-Hit Lymphoma +

Marginal Zone Lymphoma +

Transformed Lymphoma +

Osteosarcoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Medulloblastoma +

Esophageal Carcinoma +

Small Lymphocytic Lymphoma +

Prostate Carcinoma +

Colorectal Carcinoma +

Small Cell Lung Carcinoma +

Ovarian Carcinoma +

Gastric Adenocarcinoma +

Head And Neck Squamous Cell Carcinoma +

Mature B-Cell Non-Hodgkin Lymphoma +

Papillary Renal Cell Carcinoma +

Lymphoma +

Renal Cell Carcinoma +

Clear Cell Renal Cell Carcinoma +

Leiomyosarcoma +

Gastrointestinal Stromal Tumor +

B-Cell Non-Hodgkin Lymphoma +

Central Nervous System Neoplasm +

Gastric Squamous Cell Carcinoma +

Hairy Cell Leukemia +

Intraocular Lymphoma +

Lymphoplasmacytic Lymphoma +

Mature T-Cell And NK-Cell Lymphoma/Leukemia +

Multiple Myeloma +

Neuroblastoma +

Peripheral T-Cell Lymphoma +

Peritoneal Mesothelioma +

Pleural Mesothelioma +

Small Intestinal Lymphoma +

Small Lymphocytic Leukemia +

Solid Neoplasm +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.