Gene Location [1]

MYC Mutation is present in 0.92% of AACR GENIE cases, with lung adenocarcinoma, diffuse large B-cell lymphoma, not otherwise specified, endometrial endometrioid adenocarcinoma, colon adenocarcinoma, and breast invasive ductal carcinoma having the greatest prevalence [4].

Top Disease Cases with MYC Mutation

Significance of MYC Mutation in Diseases

Diffuse Large B-Cell Lymphoma +

Malignant Solid Tumor +

Hodgkin Lymphoma +

Non-Small Cell Lung Carcinoma +

Mantle Cell Lymphoma +

Non-Hodgkin Lymphoma +

Ovarian Carcinoma +

Follicular Lymphoma +

Colorectal Carcinoma +

Multiple Myeloma +

Breast Carcinoma +

Chronic Lymphocytic Leukemia +

Double-Hit Lymphoma +

Burkitt Lymphoma +

Vaginal Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Mature B-Cell Non-Hodgkin Lymphoma +

Lymphoma +

Bladder Carcinoma +

Melanoma +

Anal Carcinoma +

Cervical Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Head And Neck Carcinoma +

Glioblastoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Prostate Carcinoma +

Papillary Renal Cell Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma +

Soft Tissue Sarcoma +

Gastrointestinal Stromal Tumor +

Pleural Mesothelioma +

Sarcoma +

Pancreatic Carcinoma +

Renal Cell Carcinoma +

Anaplastic Astrocytoma +

Clear Cell Renal Cell Carcinoma +

Hairy Cell Leukemia +

Intraocular Lymphoma +

Lymphoplasmacytic Lymphoma +

Marginal Zone Lymphoma +

Mature B-Cell Lymphoma/Leukemia +

Penile Carcinoma +

Peripheral T-Cell Lymphoma +

Peritoneal Mesothelioma +

Plasma Cell Leukemia +

Small Intestinal Lymphoma +

Small Lymphocytic Leukemia +

Small Lymphocytic Lymphoma +

Triple-Hit Lymphoma +

Vulvar Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.