Gene Location [1]
Receptor tyrosine kinase/growth factor signaling, Kinase fusions
Variant Type

RET Fusion is present in 0.36% of AACR GENIE cases, with lung adenocarcinoma, thyroid gland papillary carcinoma, colon adenocarcinoma, poorly differentiated thyroid gland carcinoma, and breast invasive ductal carcinoma having the greatest prevalence [4].

Top Disease Cases with RET Fusion

Biomarker-Directed Therapies

Significance of RET Fusion in Diseases

Non-Small Cell Lung Carcinoma +

Thyroid Gland Medullary Carcinoma +

Thyroid Gland Carcinoma +

Malignant Solid Tumor +

Non-Squamous Non-Small Cell Lung Carcinoma +

Urothelial Carcinoma +

Squamous Cell Lung Carcinoma +

Renal Cell Carcinoma +

Melanoma +

Prostate Carcinoma +

Hepatocellular Carcinoma +

Multiple Myeloma +

Thyroid Gland Papillary Carcinoma +

Poorly Differentiated Thyroid Gland Carcinoma +

Lung Adenocarcinoma +

Lung Carcinoma +

Gastric Carcinoma +

Oropharyngeal Carcinoma +

Cancer +

Adenocarcinoma Of The Gastroesophageal Junction +

Malignant Salivary Gland Neoplasm +

Neuroendocrine Carcinoma +

Hepatobiliary Neoplasm +

Malignant Hepatobiliary Neoplasm +

Bladder Carcinoma +

Esophageal Carcinoma +

Colorectal Carcinoma +

Head And Neck Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Breast Carcinoma +

Malignant Central Nervous System Neoplasm +

Lymphoma +

Soft Tissue Sarcoma +

Acute Lymphoblastic Leukemia +

Acute Myeloid Leukemia +

Adrenal Cortex Carcinoma +

Adrenal Gland Pheochromocytoma +

Alveolar Soft Part Sarcoma +

B-Cell Non-Hodgkin Lymphoma +

Cervical Squamous Cell Carcinoma +

Chronic Myeloid Leukemia +

Clear Cell Sarcoma Of Soft Tissue +

Endometrial Carcinoma +

Ewing Sarcoma +

Gastrointestinal Stromal Tumor +

Hepatoblastoma +

High Grade Ovarian Serous Adenocarcinoma +

Leukemia +

Lip And Oral Cavity Carcinoma +

Malignant Laryngeal Neoplasm +

Mesothelioma +

Nasal Cavity And Paranasal Sinus Carcinoma +

Nasopharyngeal Carcinoma +

Osteosarcoma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Rhabdomyosarcoma +

Wilms Tumor +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.