Overview

Gene Location [1]
6q22.1
Pathways
Receptor tyrosine kinase/growth factor signaling, Kinase fusions
Variant Type
Fusion
Gene
ROS1

ROS1 Fusion is present in 0.29% of AACR GENIE cases, with lung adenocarcinoma, breast invasive ductal carcinoma, colon adenocarcinoma, conventional glioblastoma multiforme, and non-small cell lung carcinoma having the greatest prevalence [4].

Top Disease Cases with ROS1 Fusion

Biomarker-Directed Therapies

Significance of ROS1 Fusion in Diseases

Non-Small Cell Lung Carcinoma +

Malignant Solid Tumor +

Colorectal Carcinoma +

Cancer +

Melanoma +

Lung Carcinoma +

Breast Carcinoma +

Head And Neck Carcinoma +

Bladder Carcinoma +

Prostate Carcinoma +

Anaplastic Large Cell Lymphoma +

Non-Hodgkin Lymphoma +

Lung Adenocarcinoma +

Non-Squamous Non-Small Cell Lung Carcinoma +

Mesothelioma +

Bile Duct Carcinoma +

Malignant Central Nervous System Neoplasm +

Pancreatic Carcinoma +

Ovarian Carcinoma +

Gastric Adenocarcinoma +

Pancreatic Adenocarcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Urothelial Carcinoma +

Soft Tissue Sarcoma +

Malignant Uterine Neoplasm +

Adenocarcinoma Of The Gastroesophageal Junction +

B-Cell Non-Hodgkin Lymphoma +

Bronchogenic Carcinoma +

Cervical Carcinoma +

Cervical Squamous Cell Carcinoma +

Endometrial Carcinoma +

Esophageal Squamous Cell Carcinoma +

Gallbladder Carcinoma +

Hepatocellular Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Multiple Myeloma +

Renal Cell Carcinoma +

Squamous Cell Lung Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.