Overview

Gene Location [1]
6q22.1
Pathways
Kinase fusions, Receptor tyrosine kinase/growth factor signaling
Variant Type
Fusion
Gene
ROS1

Biomarker-Directed Therapies

Significance of ROS1 Fusion in Diseases

Non-Small Cell Lung Carcinoma +

Malignant Solid Tumor +

Cancer +

Colorectal Carcinoma +

Melanoma +

Non-Hodgkin Lymphoma +

Anaplastic Large Cell Lymphoma +

B-Cell Non-Hodgkin Lymphoma +

Bladder Carcinoma +

Breast Carcinoma +

Endometrial Carcinoma +

Head And Neck Carcinoma +

Lung Carcinoma +

Malignant Central Nervous System Neoplasm +

Multiple Myeloma +

Pancreatic Adenocarcinoma +

Prostate Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Bile Duct Carcinoma +

Bronchioloalveolar Carcinoma +

Bronchogenic Carcinoma +

Cervical Carcinoma +

Cervical Squamous Cell Carcinoma +

Esophageal Carcinoma +

Esophageal Squamous Cell Carcinoma +

Fallopian Tube Carcinoma +

Gallbladder Carcinoma +

Gastric Adenocarcinoma +

Hepatocellular Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Malignant Uterine Corpus Neoplasm +

Malignant Uterine Neoplasm +

Mesothelioma +

Ovarian Carcinoma +

Pancreatic Carcinoma +

Primary Peritoneal Carcinoma +

Renal Cell Carcinoma +

Soft Tissue Sarcoma +

Urothelial Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20171026. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.