Overview

Gene Location [1]
11p13
Pathway
Beta-Catenin/WNT signaling
Gene
WT1

WT1 Mutation is present in 1.33% of AACR GENIE cases, with non-small cell lung carcinoma, leukemia, colorectal adenocarcinoma, melanoma, and breast carcinoma having the greatest prevalence [4].

Top Disease Cases with WT1 Mutation

Significance of WT1 Mutation in Diseases

Acute Myeloid Leukemia +

Adenocarcinoma Of The Gastroesophageal Junction +

Esophageal Adenocarcinoma +

Acute Lymphoblastic Leukemia +

Non-Hodgkin Lymphoma +

Myelodysplastic Syndromes +

Gastric Adenocarcinoma +

Acute Biphenotypic Leukemia +

Acute Erythroid Leukemia +

Acute Megakaryoblastic Leukemia +

Acute Undifferentiated Leukemia +

Chronic Myeloid Leukemia +

Esophageal Squamous Cell Carcinoma +

Gastric Squamous Cell Carcinoma +

Hodgkin Lymphoma +

Juvenile Myelomonocytic Leukemia +

Myeloid Sarcoma +

Natural Killer Cell Lymphoblastic Leukemia/Lymphoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.