Overview

NCI Definition: A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts). [1]

Acute leukemias most frequently harbor alterations in DNMT3A, NPM1, ASXL1, TET2, and ETV6 [2].

Most Commonly Altered Genes in Acute Leukemia

NPM1 Mutation, NPM1 W288Cfs*12, DNMT3A Mutation, ASXL1 Mutation, and TET2 Mutation are the most common alterations in acute leukemia [2].

Top Alterations in Acute Leukemia

Significant Genes in Acute Leukemia

ABL1 +

AFF1 +

BCR +

CBFB +

DEK +

ELL +

FLT3 +

KIT +

KMT2A +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MYH11 +

NPM1 +

NUP214 +

PBX1 +

RPN1 +

RUNX1 +

RUNX1T1 +

TCF3 +

TP53 +

Disease Details

Parent(s)
Leukemia
Children
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, and Acute Leukemia of Ambiguous Lineage

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.