Overview

NCI Definition: A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts). [1]

Acute leukemias most frequently harbor alterations in NPM1, DNMT3A, ASXL1, TET2, and ETV6 [2].

Most Commonly Altered Genes in Acute Leukemia

NPM1 Mutation, NPM1 Exon 12 Mutation, NPM1 W288Cfs*12, DNMT3A Mutation, and ASXL1 Mutation are the most common alterations in acute leukemia [2].

Top Alterations in Acute Leukemia

Significant Genes in Acute Leukemia

ABL1 +

AFF1 +

BCR +

CBFB +

DEK +

ELL +

ETV6 +

FLT3 +

IKZF1 +

KIT +

KMT2A +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MYH11 +

NPM1 +

NTRK1 +

NTRK2 +

NTRK3 +

NUP214 +

PBX1 +

RPN1 +

RUNX1 +

RUNX1T1 +

TCF3 +

TP53 +

Disease Details

Synonyms
Bone marrow leukemia acute, PEDIATRIC Bone marrow leukemia acute
Parent(s)
Leukemia
Children
Acute Myeloid Leukemia, Acute Leukemia of Ambiguous Lineage, and Acute Lymphoblastic Leukemia

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.