Associated Genetic Biomarkers

Overview

NCI Definition: A clonal expansion of myeloid blasts in the bone marrow, blood or other tissues. The classification of acute myeloid leukemias (AMLs) encompasses four major categories: 1) AML with recurrent genetic abnormalities; 2) AML with multilineage dysplasia; 3) Therapy-related AML; 4) AML not otherwise specified. The required bone marrow or peripheral blood blast percentage for the diagnosis of AML is 20% (WHO classification). [1]

Biomarker-Directed Therapies

Significant Genes in Acute Myeloid Leukemia

ABL1 +

ABL2 +

AFF1 +

ARAF +

ASXL1 +

ATM +

BCL2 +

BCL6 +

BCOR +

BCR +

BIRC3 +

BRAF +

CBFA2T3 +

CBFB +

CBL +

CEBPA +

CREBBP +

CRKL +

CRLF2 +

CSF3R +

DEK +

DNMT3A +

ELL +

EPOR +

ETV6 +

EZH2 +

FBXW7 +

FGF2 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FLT1 +

FLT3 +

GATA1 +

GATA2 +

GLIS2 +

HIP1 +

HOXA9 +

HRAS +

IDH1 +

IDH2 +

IGH +

IKZF1 +

IL7R +

JAK1 +

JAK2 +

JAK3 +

KAT6A +

KDM5A +

KIT +

KMT2A +

KRAS +

LYN +

MAF +

MAFB +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MDM2 +

MDM4 +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MNX1 +

MPL +

MYC +

MYD88 +

MYH11 +

NF1 +

NOTCH1 +

NPM1 +

NRAS +

NRIP3 +

NSD1 +

NTRK1 +

NTRK2 +

NTRK3 +

NUMA1 +

NUP214 +

NUP98 +

PBX1 +

PDGFRA +

PDGFRB +

PDS5B +

PHF6 +

PML +

PPM1D +

PRDM16 +

PTEN +

PTPN11 +

RAD21 +

RAF1 +

RARA +

RB1 +

RET +

RIT1 +

RPN1 +

RUNX1 +

RUNX1T1 +

SF3B1 +

SH2B3 +

SMARCA4 +

SMARCB1 +

SMC1A +

SMC3 +

SRC +

SRSF2 +

STAG2 +

STAT3 +

TCF3 +

TET2 +

TP53 +

TRA +

TRB +

TRD +

TRG +

TYK2 +

U2AF1 +

U2AF2 +

WHSC1 +

WT1 +

ZRSR1 +

ZRSR2 +

Disease Details

Synonyms
Acute Granulocytic Leukemia, Acute Myelogenous Leukemia, ANLL, Acute Nonlymphocytic Leukemia, Acute Megakaryocytic Leukemia, acute myeloid leukaemia, AML, AML - Acute Myeloid Leukemia, Bone marrow leukemia non-lymphocytic acute myelocytic (AML), Hematopoeitic - Acute Myleogenous Leukemia (AML), Acute Myelocytic Leukemia, Acute Myelogenous Leukemias, Acute Myeloblastic Leukemia
Parent(s)
Myeloid Leukemia
Children
Acute Myeloid Leukemia Not Otherwise Specified, Acute Myeloid Leukemia with Myelodysplasia-Related Changes, Acute Myeloid Leukemia with Gene Mutations, Secondary Acute Myeloid Leukemia, Myeloid Sarcoma, Myeloid Leukemia Associated with Down Syndrome, and Acute Myeloid Leukemia with Recurrent Genetic Abnormalities
OncoTree Name
Acute Myeloid Leukemia
OncoTree Code
AML

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.