Associated Genetic Biomarkers

Overview

NCI Definition: A carcinoma arising from the intrahepatic bile ducts, hepatic ducts, common bile duct, cystic duct, or gallbladder. [1]

Biliary tract carcinomas most frequently harbor alterations in TP53, KRAS, ARID1A, CDKN2A, and IDH1 [2].

Most Commonly Altered Genes in Biliary Tract Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, KRAS Mutation, and ARID1A Mutation are the most common alterations in biliary tract carcinoma [2].

Top Alterations in Biliary Tract Carcinoma

Significant Genes in Biliary Tract Carcinoma

ALK +

ARID1A +

ATM +

ATR +

BARD1 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CD274 +

CHEK1 +

CHEK2 +

EGFR +

ERBB2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

MCPH1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

NBN +

PALB2 +

PMS1 +

PMS2 +

PTCH1 +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

SLX4 +

SMO +

Disease Details

Synonyms
Pancreatobiliary carcinoma (NOS)
Parent(s)
Malignant Hepatobiliary Neoplasm
Children
Gallbladder Carcinoma and Bile Duct Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.