Overview

NCI Definition: A benign or malignant, primary or metastatic neoplasm that affects the brain, meninges, or spinal cord. Representative examples of primary neoplasms include astrocytoma, oligodendroglioma, ependymoma, and meningioma. Representative examples of metastatic neoplasms include carcinoma and leukemia. [1]

Significant Genes in Central Nervous System Neoplasm

ALK +

APOBEC1 +

APOBEC2 +

APOBEC3A +

APOBEC3B +

APOBEC3C +

APOBEC3D +

APOBEC3F +

APOBEC3G +

APOBEC3H +

APOBEC4 +

EPCAM +

ERBB2 +

ETV6 +

MYC +

MYCN +

NTRK1 +

NTRK2 +

NTRK3 +

POLD1 +

POLE +

Disease Details

Synonyms
Tumor of the Central Nervous System, Neoplasm of Central Nervous System, Tumor of Central Nervous System, Central Nervous System Tumor, Neoplasm of CNS, CNS Neoplasm, CNS Tumor, Neoplasm of the Central Nervous System, Tumor of the CNS, Tumor of CNS
Parent(s)
Solid Neoplasm
Children
Intracranial Neoplasm, Central Nervous System Melanocytic Neoplasm, Cauda Equina Neoplasm, Benign Central Nervous System Neoplasm, Ependymal Tumor, Epidural Spinal Canal Neoplasm, Mixed Glioma, Oligodendroglial Tumor, Central Nervous System Germ Cell Tumor, Intraspinal Meningioma, Malignant Central Nervous System Neoplasm, Central Nervous System Hemangioblastoma, Meningeal Neoplasm, Intradural Extramedullary Spinal Canal Neoplasm, Neuronal and Mixed Neuronal-Glial Tumors, Spinal Cord Neoplasm, and Central Nervous System Mesenchymal Non-meningothelial Tumor
OncoTree Name
CNS/Brain
OncoTree Code
BRAIN

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.