Overview

NCI Definition: A benign or malignant, primary or metastatic neoplasm that affects the brain, meninges, or spinal cord. Representative examples of primary neoplasms include astrocytoma, oligodendroglioma, ependymoma, and meningioma. Representative examples of metastatic neoplasms include carcinoma and leukemia. [1]

Central nervous system neoplasms most frequently harbor alterations in TP53, IDH1, CDKN2A, PTEN, and CDKN2B [2].

Most Commonly Altered Genes in Central Nervous System Neoplasm

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, IDH1 Mutation, and IDH1 Codon 132 Missense are the most common alterations in central nervous system neoplasm [2].

Top Alterations in Central Nervous System Neoplasm

Significant Genes in Central Nervous System Neoplasm

ALK +

APOBEC1 +

APOBEC2 +

APOBEC3A +

APOBEC3B +

APOBEC3C +

APOBEC3D +

APOBEC3F +

APOBEC3G +

APOBEC3H +

APOBEC4 +

EPCAM +

ERBB2 +

MYC +

MYCN +

POLD1 +

POLE +

Disease Details

Synonyms
CNS Neoplasm, Central Nervous System Tumor, Neoplasm of CNS, Tumor of the Central Nervous System, Neoplasm of Central Nervous System, Tumor of CNS, Tumor of Central Nervous System, Tumor of the CNS, CNS Tumor, Neoplasm of the Central Nervous System
Parent(s)
Solid Neoplasm
Children
Spinal Cord Neoplasm, Mixed Glioma, Central Nervous System Germ Cell Tumor, Intracranial Neoplasm, Neuronal and Mixed Neuronal-Glial Tumors, Central Nervous System Hemangioblastoma, Malignant Central Nervous System Neoplasm, Meningeal Neoplasm, Cauda Equina Neoplasm, Benign Central Nervous System Neoplasm, Central Nervous System Mesenchymal Non-meningothelial Tumor, Epidural Spinal Canal Neoplasm, Oligodendroglial Tumor, Central Nervous System Melanocytic Neoplasm, Intradural Extramedullary Spinal Canal Neoplasm, Intraspinal Meningioma, and Ependymal Tumor
OncoTree Name
CNS/Brain
OncoTree Code
BRAIN

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.