Overview

NCI Definition: An adenocarcinoma arising from the cervical epithelium. It accounts for approximately 15% of invasive cervical carcinomas. Increased numbers of sexual partners and human papillomavirus (HPV) infection are risk factors. Grossly, advanced cervical adenocarcinoma may present as an exophytic mass, an ulcerated lesion, or diffuse cervical enlargement. Microscopically, the majority of cervical adenocarcinomas are of the endocervical (mucinous) type. [1]

Cervical adenocarcinomas most frequently harbor alterations in TP53, KRAS, PIK3CA, PTEN, and SMAD4 [2].

Most Commonly Altered Genes in Cervical Adenocarcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, KRAS Mutation, and PIK3CA Mutation are the most common alterations in cervical adenocarcinoma [2].

Top Alterations in Cervical Adenocarcinoma

Disease Details

Synonyms
Adenocarcinoma of the Cervix Uteri, Cervix Adenocarcinoma, Adenocarcinoma of Cervix Uteri, Uterine Cervix Adenocarcinoma, Cervix Uteri Adenocarcinoma, Adenocarcinoma of the Cervix, Adenocarcinoma of Cervix, Adenocarcinoma of Uterine Cervix, Adenocarcinoma - cervix, Adenocarcinoma of the Uterine Cervix
Parent(s)
Adenocarcinoma
Children
Cervical Mesonephric Adenocarcinoma, Cervical Villoglandular Adenocarcinoma, Early Invasive Cervical Adenocarcinoma, Cervical Adenocarcinoma In Situ, Cervical Clear Cell Adenocarcinoma, Cervical Serous Adenocarcinoma, Cervical Mucinous Adenocarcinoma, and Cervical Endometrioid Adenocarcinoma
OncoTree Name
Cervical Adenocarcinoma
OncoTree Code
CEAD

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.