Overview

NCI Definition: A squamous cell carcinoma arising from the cervical epithelium. It usually evolves from a precancerous cervical lesion. Increased numbers of sexual partners and human papillomavirus (HPV) infection are risk factors for cervical squamous cell carcinoma. The following histologic patterns have been described: conventional squamous cell carcinoma, papillary squamous cell carcinoma, transitional cell carcinoma, lymphoepithelioma-like carcinoma, verrucous carcinoma, condylomatous carcinoma and spindle cell carcinoma. Survival is most closely related to the stage of disease at the time of diagnosis. [1]

Cervical squamous cell carcinomas most frequently harbor alterations in PIK3CA, KMT2D, FBXW7, TP53, and ERBB2 [2].

Most Commonly Altered Genes in Cervical Squamous Cell Carcinoma

PIK3CA Mutation, PIK3CA E545K, KMT2D Mutation, FBXW7 Mutation, and TP53 Mutation are the most common alterations in cervical squamous cell carcinoma [2].

Top Alterations in Cervical Squamous Cell Carcinoma

Significant Genes in Cervical Squamous Cell Carcinoma

ALK +

BRAF +

BTRC +

DVL1 +

EGFR +

ERBB2 +

FZD1 +

FZD10 +

FZD2 +

FZD3 +

FZD4 +

FZD5 +

FZD6 +

FZD7 +

FZD8 +

FZD9 +

KRAS +

LRP5 +

LRP6 +

MET +

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

PMS1 +

PMS2 +

RET +

RNF43 +

ROS1 +

RSPO1 +

WNT1 +

Disease Details

Synonyms
Cervix Squamous Cell Carcinoma, Squamous Cell Carcinoma of the Uterine Cervix, Squamous Cell Carcinoma of the Cervix Uteri, Squamous cervical cancer, Squamous Cell Carcinoma of Cervix Uteri, Uterine Cervix Squamous Cell Carcinoma, Squamous Cell Carcinoma of the Cervix, Cervix Squamous Cell Carcinoma (SCC), Squamous Cell Carcinoma of Cervix, Cervix Uteri Squamous Cell Carcinoma, Squamous Cell Carcinoma of Uterine Cervix
Parent(s)
Squamous Cell Carcinoma
Children
Early Invasive Cervical Squamous Cell Carcinoma, Cervical Basaloid Carcinoma, Cervical Lymphoepithelioma-Like Carcinoma, Cervical Non-Keratinizing Squamous Cell Carcinoma, Cervical Verrucous Carcinoma, and Cervical Keratinizing Squamous Cell Carcinoma
OncoTree Name
Cervical Squamous Cell Carcinoma
OncoTree Code
CESC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.