Overview

NCI Definition: A primary melanoma arising from atypical melanocytes in the skin. Precursor lesions include acquired and congenital melanocytic nevi, and dysplastic nevi. Several histologic variants have been recognized, including superficial spreading melanoma, acral lentiginous melanoma, nodular melanoma, and lentigo maligna melanoma. [1]

Significant Genes in Cutaneous Melanoma

ARAF +

BRAF +

CRKL +

GNA11 +

GNAQ +

HRAS +

KRAS +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

NF1 +

NRAS +

PRKCA +

PRKCB +

PRKCD +

PRKCE +

PRKCG +

PRKCI +

PRKCQ +

PRKCZ +

RAF1 +

SRC +

Disease Details

Synonyms
Melanoma of Skin, Malignant Melanoma of Skin Stage Unspecified, Malignant Cutaneous Melanoma, Malignant Melanoma of Skin, Skin Melanoma, Skin, Melanoma, Malignant Melanoma (of Skin), Stage Unspecified, Melanoma of the Skin
Parent(s)
Melanoma
Children
Desmoplastic Melanoma, Lentigo Maligna Melanoma, Scrotal Melanoma, Amelanotic Skin Melanoma, Balloon Cell Melanoma, Acral Lentiginous Melanoma, Nodular Melanoma, and Spitzoid Melanoma
OncoTree Name
Cutaneous Melanoma
OncoTree Code
SKCM

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.