Overview

NCI Definition: A squamous cell carcinoma arising from the esophagus. It is associated with a long history of tobacco and alcohol abuse and is exceedingly rare before the age of 30. The median age is around 65 in both males and females. It is located mostly in the middle and lower third of the esophagus. Grossly, polypoid, ulcerated, plaque-like and occult lesions have been described. The microscopic features are the same as in other squamous cell carcinomas. Any degree of differentiation may occur, and variation within a single tumor is common. The prognosis is poor. [1]

Significant Genes in Esophageal Squamous Cell Carcinoma

AKT1 +

ALK +

APC +

ATM +

ATR +

BRAF +

BRCA1 +

BRCA2 +

BTRC +

CCND1 +

CDK12 +

CDK4 +

CDK6 +

CDKN2A +

CHEK2 +

CSF1R +

CTNNB1 +

DDX3X +

DVL1 +

EGFR +

EPCAM +

ERBB2 +

ERBB3 +

EXO1 +

FANCA +

FGFR1 +

FGFR2 +

FGFR3 +

FLT1 +

FLT3 +

FLT4 +

FZD1 +

FZD10 +

FZD2 +

FZD3 +

FZD4 +

FZD5 +

FZD6 +

FZD7 +

FZD8 +

FZD9 +

KDR +

KIT +

KMT2D +

KRAS +

LRP5 +

LRP6 +

MET +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MST1R +

MTOR +

MYC +

NBN +

NRG1 +

NTRK1 +

NTRK2 +

NTRK3 +

PALB2 +

PCNA +

PDGFRA +

PDGFRB +

PIK3CA +

PMS1 +

PMS2 +

POLD1 +

POLE +

RAD51C +

RAF1 +

RET +

RFC1 +

RFC2 +

RFC3 +

RFC4 +

RFC5 +

RNF43 +

ROS1 +

RPA1 +

RPA2 +

RPA3 +

RPA4 +

RSPO1 +

SMARCA4 +

SSBP1 +

TP53 +

TSC1 +

TSC2 +

VHL +

WNT1 +

Disease Details

Synonyms
Esophagus Squamous Cell Carcinoma, Squamous Cell Carcinoma of the Esophagus, Esophagus squamous cell carcinoma (SCC), SCC of the Esophagus, ESCC, Esophageal Epidermoid Carcinoma, Squamous Cell Carcinoma of Esophagus, Esophageal SCC, Esophagus SCC, SCC of Esophagus, Squamous cell car. - esophagus
Parent(s)
Squamous Cell Carcinoma
Children
Esophageal Verrucous Carcinoma, Esophageal Basaloid Carcinoma, and Distal Esophagus Squamous Cell Carcinoma
OncoTree Name
Esophageal Squamous Cell Carcinoma
OncoTree Code
ESCC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.