Overview

NCI Definition: A squamous cell carcinoma arising from the esophagus. It is associated with a long history of tobacco and alcohol abuse and is exceedingly rare before the age of 30. The median age is around 65 in both males and females. It is located mostly in the middle and lower third of the esophagus. Grossly, polypoid, ulcerated, plaque-like and occult lesions have been described. The microscopic features are the same as in other squamous cell carcinomas. Any degree of differentiation may occur, and variation within a single tumor is common. The prognosis is poor. [1]

Esophageal squamous cell carcinomas most frequently harbor alterations in TP53, CDKN2A, CCND1, NOTCH1, and CDKN2B [2].

Most Commonly Altered Genes in Esophageal Squamous Cell Carcinoma

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, CCND1 Amplification, and CDKN2A Loss are the most common alterations in esophageal squamous cell carcinoma [2].

Top Alterations in Esophageal Squamous Cell Carcinoma

Significant Genes in Esophageal Squamous Cell Carcinoma

AKT1 +

ALK +

APC +

ATM +

BRAF +

BRCA1 +

BRCA2 +

BTRC +

CCND1 +

CDK4 +

CDK6 +

CDKN2A +

CSF1R +

CTNNB1 +

DDX3X +

DVL1 +

EGFR +

EPCAM +

ERBB2 +

ERBB3 +

EXO1 +

FGFR1 +

FGFR2 +

FGFR3 +

FLT1 +

FLT3 +

FLT4 +

FZD1 +

FZD10 +

FZD2 +

FZD3 +

FZD4 +

FZD5 +

FZD6 +

FZD7 +

FZD8 +

FZD9 +

KDR +

KIT +

KMT2D +

KRAS +

LRP5 +

LRP6 +

MET +

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

MST1R +

MTOR +

MYC +

NRG1 +

PALB2 +

PCNA +

PDGFRA +

PDGFRB +

PIK3CA +

PMS1 +

PMS2 +

POLD1 +

POLE +

RAF1 +

RET +

RFC1 +

RFC2 +

RFC3 +

RFC4 +

RFC5 +

RNF43 +

ROS1 +

RPA1 +

RPA2 +

RPA3 +

RPA4 +

RSPO1 +

SMARCA4 +

SSBP1 +

TP53 +

TSC1 +

TSC2 +

VHL +

WNT1 +

Disease Details

Synonyms
SCC of Esophagus, Squamous cell car. - esophagus, SCC of the Esophagus, Esophagus SCC, Esophageal Epidermoid Carcinoma, Esophagus Squamous Cell Carcinoma, Esophagus squamous cell carcinoma (SCC), Squamous Cell Carcinoma of the Esophagus, Squamous Cell Carcinoma of Esophagus, Esophageal SCC, ESCC
Parent(s)
Squamous Cell Carcinoma
Children
Esophageal Verrucous Carcinoma and Esophageal Basaloid Carcinoma
OncoTree Name
Esophageal Squamous Cell Carcinoma
OncoTree Code
ESCC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.