Overview

NCI Definition: A squamous cell carcinoma arising from the esophagus. It is associated with a long history of tobacco and alcohol abuse and is exceedingly rare before the age of 30. The median age is around 65 in both males and females. It is located mostly in the middle and lower third of the esophagus. Grossly, polypoid, ulcerated, plaque-like and occult lesions have been described. The microscopic features are the same as in other squamous cell carcinomas. Any degree of differentiation may occur, and variation within a single tumor is common. The prognosis is poor. [1]

Esophageal squamous cell carcinomas most frequently harbor alterations in TP53, CDKN2A, CCND1, NOTCH1, and CDKN2B [2].

Most Commonly Altered Genes in Esophageal Squamous Cell Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in esophageal squamous cell carcinoma [2].

Top Alterations in Esophageal Squamous Cell Carcinoma

Significant Genes in Esophageal Squamous Cell Carcinoma

APC +

AXIN1 +

BRAF +

BTRC +

CSNK1A1 +

CTNNA1 +

CTNNB1 +

DVL1 +

ERBB2 +

FZD1 +

FZD10 +

FZD2 +

FZD3 +

FZD4 +

FZD5 +

FZD6 +

FZD7 +

FZD8 +

FZD9 +

GSK3B +

LRP5 +

LRP6 +

RNF43 +

RSPO1 +

TP53 +

WISP3 +

WNT1 +

WT1 +

Disease Details

Synonyms
Squamous cell car. - esophagus, ESCC, SCC of Esophagus, Squamous Cell Carcinoma of Esophagus, Esophagus Squamous Cell Carcinoma, Esophagus SCC, SCC of the Esophagus, Squamous Cell Carcinoma of the Esophagus, Esophageal SCC, Esophageal Epidermoid Carcinoma
Parent(s)
Squamous Cell Carcinoma
Children
Esophageal Basaloid Carcinoma and Esophageal Verrucous Carcinoma
OncoTree Name
Esophageal Squamous Cell Carcinoma
OncoTree Code
ESCC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.