Associated Genetic Biomarkers

Overview

NCI Definition: An adenocarcinoma arising from the stomach glandular epithelium. Gastric adenocarcinoma is primarily a disease of older individuals. It most commonly develops after a long period of atrophic gastritis and is strongly associated with Helicobacter pylori infection. The lack of early symptoms often delays the diagnosis of gastric cancer. The majority of patients present with advanced tumors which have poor rates of curability. Microscopically, two important histologic types of gastric adenocarcinoma are recognized: the intestinal and diffuse type. The overall prognosis of gastric adenocarcinomas is poor, even in patients who receive a "curative" resection (adapted from Sternberg's Surgical Pathology, 3rd ed., 1999). [1]

Gastric adenocarcinomas most frequently harbor alterations in TP53, CDH1, ARID1A, KRAS, and ERBB2 [2].

Most Commonly Altered Genes in Gastric Adenocarcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in gastric adenocarcinoma [2].

Top Alterations in Gastric Adenocarcinoma

Significant Genes in Gastric Adenocarcinoma

AKT1 +

AKT2 +

AKT3 +

APC +

ARID1A +

ATM +

AXIN1 +

BARD1 +

BRCA1 +

BRCA2 +

BRIP1 +

BTRC +

CDK12 +

CHEK2 +

CRKL +

CSNK1A1 +

CTNNA1 +

CTNNB1 +

DVL1 +

EGFR +

ERBB2 +

FANCA +

FGFR2 +

FZD1 +

FZD10 +

FZD2 +

FZD3 +

FZD4 +

FZD5 +

FZD6 +

FZD7 +

FZD8 +

FZD9 +

GEN1 +

GSK3B +

IRS2 +

KIT +

KRAS +

LRP5 +

LRP6 +

MET +

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

MTOR +

MYC +

NBN +

NRAS +

PALB2 +

PDGFRA +

PIK3CA +

PIK3CB +

PIK3CG +

PIK3R1 +

PIK3R2 +

PMS1 +

PMS2 +

PTEN +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RICTOR +

RNF43 +

RPTOR +

TP53 +

TSC1 +

TSC2 +

UGT1A1 +

WISP3 +

WNT1 +

WT1 +

Disease Details

Synonyms
Adenocarcinoma of the Stomach, Adenocarcinoma of Stomach, Adenocarcinoma - stomach, Stomach Adenocarcinoma
Parent(s)
Gastric Carcinoma
Children
Gastric Papillary Adenocarcinoma, Sporadic Gastric Adenocarcinoma, Gastric Diffuse Adenocarcinoma, Early Gastric Cancer, Poorly Differentiated Gastric Carcinoma, Diffuse Gastric Adenocarcinoma, and Gastric Tubular Adenocarcinoma
OncoTree Name
Stomach Adenocarcinoma
OncoTree Code
STAD

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.