Associated Genetic Biomarkers

Overview

NCI Definition: A carcinoma that arises from the head and neck region. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma. [1]

Significant Genes in Head and Neck Carcinoma

ABL2 +

ACVR1B +

ALK +

APC +

ASXL1 +

ATM +

ATR +

BARD1 +

BLM +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

BTRC +

CDK12 +

CDKN1A +

CDKN1B +

CDKN2A +

CHD4 +

CHEK1 +

CHEK2 +

CYLD +

DICER1 +

DNMT3A +

DVL1 +

EGFR +

ERBB2 +

ERBB3 +

EZH2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FGFR2 +

FLT3 +

FZD1 +

FZD10 +

FZD2 +

FZD3 +

FZD4 +

FZD5 +

FZD6 +

FZD7 +

FZD8 +

FZD9 +

GATA3 +

HGF +

IDH1 +

KDM6A +

KDR +

KEAP1 +

KIT +

KMT2D +

KRAS +

LRP5 +

LRP6 +

MAGI2 +

MAP3K1 +

MCPH1 +

MED12 +

MET +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MYC +

NBN +

NF1 +

NF2 +

NOTCH1 +

NOTCH2 +

NRAS +

NSD1 +

PALB2 +

PIK3C2B +

PIK3CA +

PIK3CB +

PIK3R1 +

PMS1 +

PMS2 +

POLE +

PTCH1 +

PTEN +

PTPN11 +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RB1 +

RET +

RNF43 +

ROS1 +

RSPO1 +

RUNX1 +

SETD2 +

SLX4 +

SMARCA4 +

SOX9 +

STAG2 +

TAF1 +

TBX3 +

TET2 +

TP53 +

WNT1 +

XPO1 +

Disease Details

Synonyms
Carcinoma of the Head and Neck, Carcinoma of Head and Neck
Parent(s)
Malignant Head and Neck Neoplasm
Children
Nasopharyngeal Carcinoma, Paranasal Sinus Carcinoma, Nasal Cavity and Paranasal Sinus Carcinoma, Malignant Odontogenic Neoplasm, Salivary Gland Carcinoma, Hypopharyngeal Carcinoma, Carcinoma ex Pleomorphic Adenoma, Neck Carcinoma, Head and Neck Neuroendocrine Carcinoma, NUT Midline Carcinoma of the Head and Neck, Oropharyngeal Carcinoma, Laryngeal Carcinoma, External Ear Carcinoma, Lip and Oral Cavity Carcinoma, Middle Ear Carcinoma, Lacrimal Gland Carcinoma, and Head and Neck Squamous Cell Carcinoma
OncoTree Name
Head and Neck Carcinoma, Other
OncoTree Code
OHNCA

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.