Associated Genetic Biomarkers

Overview

NCI Definition: A carcinoma that arises from the head and neck region. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma. [1]

Significant Genes in Head and Neck Carcinoma

ABL2 +

ACVR1B +

AKT1 +

ALK +

APC +

ASXL1 +

ATM +

ATR +

BARD1 +

BLM +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

BTRC +

CCND1 +

CDK12 +

CDK4 +

CDK6 +

CDKN1A +

CDKN1B +

CDKN2A +

CHD4 +

CHEK1 +

CHEK2 +

CSF1R +

CYLD +

DICER1 +

DNMT3A +

DVL1 +

EGFR +

EPCAM +

ERBB2 +

ERBB3 +

EXO1 +

EZH2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FGFR1 +

FGFR2 +

FGFR3 +

FLT1 +

FLT3 +

FLT4 +

FZD1 +

FZD10 +

FZD2 +

FZD3 +

FZD4 +

FZD5 +

FZD6 +

FZD7 +

FZD8 +

FZD9 +

GATA3 +

HGF +

IDH1 +

KDM6A +

KDR +

KEAP1 +

KIT +

KMT2D +

KRAS +

LRP5 +

LRP6 +

MAGI2 +

MAP3K1 +

MCPH1 +

MED12 +

MET +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MST1R +

MTOR +

MYC +

NBN +

NF1 +

NF2 +

NOTCH1 +

NOTCH2 +

NRAS +

NRG1 +

NSD1 +

PALB2 +

PCNA +

PDGFRA +

PDGFRB +

PIK3C2B +

PIK3CA +

PIK3CB +

PIK3R1 +

PMS1 +

PMS2 +

POLD1 +

POLE +

PTCH1 +

PTEN +

PTPN11 +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAF1 +

RB1 +

RET +

RFC1 +

RFC2 +

RFC3 +

RFC4 +

RFC5 +

RNF43 +

ROS1 +

RPA1 +

RPA2 +

RPA3 +

RPA4 +

RSPO1 +

RUNX1 +

SETD2 +

SLX4 +

SMARCA4 +

SOX9 +

SSBP1 +

STAG2 +

TAF1 +

TBX3 +

TET2 +

TP53 +

TSC1 +

TSC2 +

VHL +

WNT1 +

XPO1 +

Disease Details

Synonyms
Carcinoma of Head and Neck, Carcinoma of the Head and Neck
Parent(s)
Malignant Head and Neck Neoplasm
Children
Hypopharyngeal Carcinoma, Head and Neck Squamous Cell Carcinoma, Paranasal Sinus Carcinoma, Lacrimal Gland Carcinoma, Carcinoma ex Pleomorphic Adenoma, NUT Midline Carcinoma of the Head and Neck, Nasal Cavity and Paranasal Sinus Carcinoma, Lip and Oral Cavity Carcinoma, Oropharyngeal Carcinoma, Malignant Odontogenic Neoplasm, Middle Ear Carcinoma, Nasopharyngeal Carcinoma, Head and Neck Neuroendocrine Carcinoma, Neck Carcinoma, Laryngeal Carcinoma, Salivary Gland Carcinoma, and External Ear Carcinoma
OncoTree Name
Head and Neck Carcinoma, Other
OncoTree Code
OHNCA

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.