Associated Genetic Biomarkers

Overview

NCI Definition: A carcinoma that arises from the head and neck region. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma. [1]

Significant Genes in Head and Neck Carcinoma

ABL2 +

ACVR1B +

AKT1 +

ALK +

APC +

ASXL1 +

ATM +

ATR +

BARD1 +

BLM +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

BTRC +

CCND1 +

CDK12 +

CDK4 +

CDK6 +

CDKN1A +

CDKN1B +

CDKN2A +

CHD4 +

CHEK1 +

CHEK2 +

CSF1R +

CYLD +

DICER1 +

DNMT3A +

DVL1 +

EGFR +

EPCAM +

ERBB2 +

ERBB3 +

EXO1 +

EZH2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FGFR1 +

FGFR2 +

FGFR3 +

FLT1 +

FLT3 +

FLT4 +

FZD1 +

FZD10 +

FZD2 +

FZD3 +

FZD4 +

FZD5 +

FZD6 +

FZD7 +

FZD8 +

FZD9 +

GATA3 +

HGF +

IDH1 +

KDM6A +

KDR +

KEAP1 +

KIT +

KMT2D +

KRAS +

LRP5 +

LRP6 +

MAGI2 +

MAP3K1 +

MCPH1 +

MED12 +

MET +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MST1R +

MTOR +

MYC +

NBN +

NF1 +

NF2 +

NOTCH1 +

NOTCH2 +

NRAS +

NRG1 +

NSD1 +

NTRK1 +

NTRK2 +

NTRK3 +

PALB2 +

PCNA +

PDGFRA +

PDGFRB +

PIK3C2B +

PIK3CA +

PIK3CB +

PIK3R1 +

PMS1 +

PMS2 +

POLD1 +

POLE +

PTCH1 +

PTEN +

PTPN11 +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RAF1 +

RB1 +

RET +

RFC1 +

RFC2 +

RFC3 +

RFC4 +

RFC5 +

RNF43 +

ROS1 +

RPA1 +

RPA2 +

RPA3 +

RPA4 +

RSPO1 +

RUNX1 +

SETD2 +

SLX4 +

SMARCA4 +

SOX9 +

SSBP1 +

STAG2 +

TAF1 +

TBX3 +

TET2 +

TP53 +

TSC1 +

TSC2 +

VHL +

WNT1 +

XPO1 +

Disease Details

Synonyms
Head and neck carcinoma (NOS), Carcinoma of the Head and Neck, Carcinoma of Head and Neck
Parent(s)
Malignant Head and Neck Neoplasm
Children
Nasal Cavity and Paranasal Sinus Carcinoma, Middle Ear Carcinoma, Salivary Gland Carcinoma, Paranasal Sinus Carcinoma, Oropharyngeal Carcinoma, Laryngeal Carcinoma, Lip and Oral Cavity Carcinoma, Nasopharyngeal Carcinoma, Head and Neck Squamous Cell Carcinoma, Neck Carcinoma, Hypopharyngeal Carcinoma, External Ear Carcinoma, Lacrimal Gland Carcinoma, Malignant Odontogenic Neoplasm, Carcinoma ex Pleomorphic Adenoma, Head and Neck Neuroendocrine Carcinoma, and NUT Midline Carcinoma of the Head and Neck
OncoTree Name
Head and Neck Carcinoma, Other
OncoTree Code
OHNCA

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.