Associated Genetic Biomarkers

Overview

NCI Definition: A carcinoma that arises from the head and neck region. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma. [1]

Head and neck carcinomas most frequently harbor alterations in TP53, CDKN2A, PIK3CA, KMT2D, and NOTCH1 [2].

Most Commonly Altered Genes in Head and Neck Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in head and neck carcinoma [2].

Top Alterations in Head and Neck Carcinoma

Significant Genes in Head and Neck Carcinoma

ABL2 +

ACVR1B +

APC +

ASXL1 +

ATM +

ATR +

BLM +

BRAF +

BRCA1 +

BRCA2 +

BTRC +

CDK12 +

CDKN1A +

CDKN1B +

CDKN2A +

CHD4 +

CYLD +

DICER1 +

DNMT3A +

DVL1 +

ERBB2 +

ERBB3 +

EZH2 +

FGFR2 +

FLT3 +

FZD1 +

FZD10 +

FZD2 +

FZD3 +

FZD4 +

FZD5 +

FZD6 +

FZD7 +

FZD8 +

FZD9 +

GATA3 +

HGF +

IDH1 +

KDM6A +

KDR +

KEAP1 +

KIT +

KMT2D +

KRAS +

LRP5 +

LRP6 +

MAGI2 +

MAP3K1 +

MED12 +

MET +

MGMT +

MLH1 +

MSH2 +

MSH6 +

MYC +

NF1 +

NF2 +

NOTCH1 +

NOTCH2 +

NRAS +

NSD1 +

PIK3C2B +

PIK3CA +

PIK3CB +

PIK3R1 +

PMS2 +

POLE +

PTCH1 +

PTPN11 +

RB1 +

RNF43 +

RSPO1 +

RUNX1 +

SETD2 +

SMARCA4 +

SOX9 +

STAG2 +

TAF1 +

TBX3 +

TET2 +

TP53 +

WNT1 +

XPO1 +

Disease Details

Synonyms
Carcinoma of the Head and Neck, Carcinoma of Head and Neck
Parent(s)
Malignant Head and Neck Neoplasm
Children
Malignant Odontogenic Neoplasm, Head and Neck Neuroendocrine Carcinoma, Paranasal Sinus Carcinoma, NUT Midline Carcinoma of the Head and Neck, Carcinoma ex Pleomorphic Adenoma, Head and Neck Squamous Cell Carcinoma, Lacrimal Gland Carcinoma, Salivary Gland Carcinoma, Nasopharyngeal Carcinoma, and Lip and Oral Cavity Carcinoma
OncoTree Name
Head and Neck Carcinoma, Other
OncoTree Code
OHNCA

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.