Overview

NCI Definition: A carcinoma that infiltrates the breast parenchyma. The vast majority are adenocarcinomas arising from the terminal ductal lobular unit (TDLU). Often, the invasive adenocarcinoma co-exists with ductal or lobular carcinoma in situ. It is the most common carcinoma affecting women. [1]

Invasive breast carcinomas most frequently harbor alterations in TP53, PIK3CA, ERBB2, GATA3, and CCND1 [2].

Most Commonly Altered Genes in Invasive Breast Carcinoma

TP53 Mutation, PIK3CA Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, and PIK3CA H1047R are the most common alterations in invasive breast carcinoma [2].

Top Alterations in Invasive Breast Carcinoma

Significant Genes in Invasive Breast Carcinoma

BRCA1 +

BRCA2 +

ERBB2 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

PIK3CA +

Disease Details

Synonyms
Invasive Mammary Carcinoma, Invasive breast carcinoma, Infiltrating Breast Carcinoma, Infiltrating Carcinoma of Breast, invasive breast cancer, Invasive Carcinoma of the Breast, Infiltrating Carcinoma of the Breast, Invasive Carcinoma of Breast, Invasive Breast Cancer, infiltrating breast cancer
Parent(s)
Breast Carcinoma
Children
Signet Ring Cell Breast Carcinoma, Metaplastic Breast Carcinoma, Adenoid Cystic Breast Carcinoma, Inflammatory Breast Carcinoma, Adenosquamous Breast Carcinoma, Breast Invasive Lobular Carcinoma, Breast Large Cell Neuroendocrine Carcinoma, Mucoepidermoid Breast Carcinoma, Breast Invasive Ductal Carcinoma, and Invasive Breast Carcinoma, NOS
OncoTree Name
Invasive Breast Carcinoma
OncoTree Code
BRCA

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.