Associated Genetic Biomarkers

Overview

NCI Definition: A carcinoma that infiltrates the breast parenchyma. The vast majority are adenocarcinomas arising from the terminal ductal lobular unit (TDLU). Often, the invasive adenocarcinoma co-exists with ductal or lobular carcinoma in situ. It is the most common carcinoma affecting women. [1]

Significant Genes in Invasive Breast Carcinoma

ATM +

ATR +

BARD1 +

BRCA1 +

BRCA2 +

BRIP1 +

CHEK2 +

ERBB2 +

FANCA +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCM +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

MRE11A +

NBN +

PALB2 +

PIK3CA +

RAD50 +

RAD51C +

RAD51D +

Disease Details

Synonyms
Invasive Mammary Carcinoma, Invasive Carcinoma of the Breast, Invasive Breast Cancer, Infiltrating Carcinoma of Breast, Infiltrating Carcinoma of the Breast, Infiltrating Breast Carcinoma, invasive breast cancer, Invasive Carcinoma of Breast, Invasive breast carcinoma, infiltrating breast cancer
Parent(s)
Breast Carcinoma
Children
Adenoid Cystic Breast Carcinoma, Invasive Papillary Breast Carcinoma, Mucoepidermoid Breast Carcinoma, Breast Invasive Ductal Carcinoma, Metaplastic Breast Carcinoma, Invasive Breast Cribriform Carcinoma, Adenosquamous Breast Carcinoma, Inflammatory Breast Carcinoma, Breast Invasive Lobular Carcinoma, Invasive Breast Carcinoma, NOS, Signet Ring Cell Breast Carcinoma, Breast Neuroendocrine Carcinoma, and Squamous Cell Breast Carcinoma
OncoTree Name
Invasive Breast Carcinoma
OncoTree Code
BRCA

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.