Overview

NCI Definition: A poorly differentiated non-small cell lung carcinoma composed of large polygonal cells without evidence of glandular or squamous differentiation. There is a male predilection. [1]

Large cell lung carcinomas most frequently harbor alterations in TP53, STK11, KRAS, SMARCA4, and KEAP1 [2].

Most Commonly Altered Genes in Large Cell Lung Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, TP53 Exon 5 Mutation, and KRAS Mutation are the most common alterations in large cell lung carcinoma [2].

Top Alterations in Large Cell Lung Carcinoma

Disease Details

Synonyms
Anaplastic Lung Carcinoma, Large Cell Carcinoma of Lung, Large Cell Carcinoma of the Lung, Lung large cell carcinoma, Large Cell Undifferentiated Lung Carcinoma
Parent(s)
Non-Squamous Non-Small Cell Lung Carcinoma
Children
Large Cell Lung Carcinoma, Clear Cell Variant, Basaloid Large Cell Lung Carcinoma, Occult Large Cell Lung Carcinoma, Lymphoepithelioma-Like Lung Carcinoma, Lung Giant Cell Carcinoma, and Large Cell Lung Carcinoma with Rhabdoid Phenotype
OncoTree Name
Large Cell Lung Carcinoma
OncoTree Code
LCLC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.