NCI Definition: A poorly differentiated non-small cell lung carcinoma composed of large polygonal cells without evidence of glandular or squamous differentiation. There is a male predilection. [1]

Large cell lung carcinomas most frequently harbor alterations in TP53, KRAS, STK11, KEAP1, and CDKN2A [2].

Most Commonly Altered Genes in Large Cell Lung Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, KRAS Mutation, and KRAS Exon 2 Mutation are the most common alterations in large cell lung carcinoma [2].

Top Alterations in Large Cell Lung Carcinoma

Disease Details

Large Cell Undifferentiated Lung Carcinoma, Large Cell Carcinoma of Lung, Anaplastic Lung Carcinoma, Large Cell Carcinoma of the Lung
Large Cell Carcinoma
Basaloid Large Cell Lung Carcinoma, Large Cell Lung Carcinoma, Clear Cell Variant, Lymphoepithelioma-Like Lung Carcinoma, Occult Large Cell Lung Carcinoma, Large Cell Lung Carcinoma with Rhabdoid Phenotype, Combined Large Cell Lung Neuroendocrine Carcinoma, and Lung Giant Cell Carcinoma
OncoTree Name
Large Cell Lung Carcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.