Overview

NCI Definition: A carcinoma originating in the lung. Lung carcinomas usually arise from the epithelium that lines the bronchial tree (bronchogenic carcinomas), and are classified as small cell or non-small cell carcinomas. Non-small cell lung carcinomas are usually adenocarcinomas, squamous cell carcinomas, or large cell carcinomas. Metastatic carcinomas to the lung are also common, and can be difficult to distinguish from primary tumors. [1]

Significant Genes in Lung Carcinoma

AKT1 +

ALK +

ATM +

ATR +

BRAF +

BRCA1 +

BRCA2 +

CCND1 +

CDK12 +

CDK4 +

CDK6 +

CDKN2A +

CHEK2 +

CSF1R +

EGFR +

EPCAM +

ERBB2 +

ERBB3 +

EXO1 +

FANCA +

FGFR1 +

FGFR2 +

FGFR3 +

FLT1 +

FLT3 +

FLT4 +

KDR +

KIT +

KRAS +

MET +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MST1R +

MTOR +

NBN +

NRAS +

NRG1 +

NTRK1 +

NTRK2 +

NTRK3 +

PALB2 +

PCNA +

PDGFRA +

PDGFRB +

PIK3CA +

PMS1 +

PMS2 +

POLD1 +

POLE +

RAD51C +

RAF1 +

RET +

RFC1 +

RFC2 +

RFC3 +

RFC4 +

RFC5 +

ROS1 +

RPA1 +

RPA2 +

RPA3 +

RPA4 +

SSBP1 +

TSC1 +

TSC2 +

VHL +

Disease Details

Synonyms
Carcinoma of the Lung, Cancer of the Lung, Lung cancer, NOS, Poorly Differentiated Carcinoma c/w Lung Primary, Carcinoma c/w Lung Primary, Lung Cancer, Carcinoma of Lung, Cancer of Lung
Parent(s)
Malignant Lung Neoplasm
Children
Primary Pulmonary Salivary Gland-Type Tumor, Asbestos-Related Lung Carcinoma, Superior Sulcus Lung Carcinoma, Bronchogenic Carcinoma, Lung Mucoepidermoid Carcinoma, Non-Small Cell Lung Carcinoma, Lung Neuroendocrine Carcinoma, Lung Hilum Carcinoma, NUT Carcinoma of the Lung, and Lung Adenoid Cystic Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.