Overview

NCI Definition: A carcinoma originating in the lung. Lung carcinomas usually arise from the epithelium that lines the bronchial tree (bronchogenic carcinomas), and are classified as small cell or non-small cell carcinomas. Non-small cell lung carcinomas are usually adenocarcinomas, squamous cell carcinomas, or large cell carcinomas. Metastatic carcinomas to the lung are also common, and can be difficult to distinguish from primary tumors. [1]

Lung carcinomas most frequently harbor alterations in TP53, KRAS, EGFR, CDKN2A, and STK11 [2].

Most Commonly Altered Genes in Lung Carcinoma

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, KRAS Mutation, and KRAS Exon 2 Mutation are the most common alterations in lung carcinoma [2].

Top Alterations in Lung Carcinoma

Significant Genes in Lung Carcinoma

AKT1 +

ALK +

ATM +

BRAF +

BRCA1 +

BRCA2 +

CCND1 +

CDK4 +

CDK6 +

CDKN2A +

CSF1R +

EGFR +

EPCAM +

ERBB2 +

ERBB3 +

EXO1 +

FGFR1 +

FGFR2 +

FGFR3 +

FLT1 +

FLT3 +

FLT4 +

KDR +

KIT +

KRAS +

MET +

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

MST1R +

MTOR +

NRAS +

NRG1 +

PALB2 +

PCNA +

PDGFRA +

PDGFRB +

PIK3CA +

PMS1 +

PMS2 +

POLD1 +

POLE +

RAF1 +

RET +

RFC1 +

RFC2 +

RFC3 +

RFC4 +

RFC5 +

ROS1 +

RPA1 +

RPA2 +

RPA3 +

RPA4 +

SSBP1 +

TSC1 +

TSC2 +

VHL +

Disease Details

Synonyms
Cancer of Lung, Carcinoma of Lung, Cancer of the Lung, Carcinoma of the Lung, Lung cancer, NOS, Lung Cancer
Parent(s)
Malignant Lung Neoplasm
Children
Lung Adenoid Cystic Carcinoma, Lung Hilum Carcinoma, Bronchogenic Carcinoma, Large Cell Lung Neuroendocrine Carcinoma, Lung Mucoepidermoid Carcinoma, NUT Carcinoma of the Lung, Superior Sulcus Lung Carcinoma, Small Cell Lung Carcinoma, Asbestos-Related Lung Carcinoma, Primary Pulmonary Salivary Gland-Type Tumor, and Non-Small Cell Lung Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.