Overview

NCI Definition: A carcinoma originating in the lung. Lung carcinomas usually arise from the epithelium that lines the bronchial tree (bronchogenic carcinomas), and are classified as small cell or non-small cell carcinomas. Non-small cell lung carcinomas are usually adenocarcinomas, squamous cell carcinomas, or large cell carcinomas. Metastatic carcinomas to the lung are also common, and can be difficult to distinguish from primary tumors. [1]

Lung carcinomas most frequently harbor alterations in TP53, RB1, CDKN2A, KMT2D, and PIK3CA [2].

Most Commonly Altered Genes in Lung Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in lung carcinoma [2].

Top Alterations in Lung Carcinoma

Significant Genes in Lung Carcinoma

ALK +

BRAF +

EGFR +

ERBB2 +

KRAS +

RET +

ROS1 +

Disease Details

Synonyms
Carcinoma of the Lung, Cancer of the Lung, Cancer of Lung, Lung cancer, NOS, Lung Cancer, Carcinoma of Lung
Parent(s)
Malignant Lung Neoplasm
Children
Large Cell Lung Neuroendocrine Carcinoma, Superior Sulcus Lung Carcinoma, Lung Hilum Carcinoma, Lung Adenocarcinoma In Situ, Asbestos-Related Lung Carcinoma, Lung Adenoid Cystic Carcinoma, Squamous Cell Lung Carcinoma, Primary Pulmonary Salivary Gland-Type Tumor, Lung Mucoepidermoid Carcinoma, Small Cell Lung Carcinoma, Non-Small Cell Lung Carcinoma, and Bronchogenic Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.