Overview

NCI Definition: A malignant neoplasm of the pleura or peritoneum, arising from mesothelial cells. It is associated with exposure to asbestos. [1]

Significant Genes in Malignant Mesothelioma

ATM +

ATR +

BAP1 +

BARD1 +

BRCA1 +

BRCA2 +

BRIP1 +

CDK12 +

CHEK1 +

CHEK2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

MCPH1 +

MRE11A +

NBN +

NF2 +

PALB2 +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

SLX4 +

Disease Details

Synonyms
Malignant Tumor of the Mesothelium, Malignant Neoplasm c/w Malignant Mesothelioma, MESOTHELIOMA, MALIGNANT, Malignant Tumor of Mesothelium, Malignant Neoplasm of the Mesothelium, Malignant Mesothelial Neoplasm, Malignant Mesothelial Tumor, Malignant Neoplasm of Mesothelium
Parent(s)
Mesothelioma
Children
Diffuse Malignant Mesothelioma, Malignant Pleural Mesothelioma, Pericardial Malignant Mesothelioma, Peritoneal Malignant Mesothelioma, and Ovarian Malignant Mesothelioma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.