Overview

NCI Definition: A malignant neoplasm of the pleura or peritoneum, arising from mesothelial cells. It is associated with exposure to asbestos. [1]

Malignant mesotheliomas most frequently harbor alterations in BAP1, NF2, CDKN2A, CDKN2B, and TP53 [2].

Most Commonly Altered Genes in Malignant Mesothelioma

CDKN2A Loss, CDKN2B Loss, BAP1 Mutation, BAP1fs, and NF2 Mutation are the most common alterations in malignant mesothelioma [2].

Top Alterations in Malignant Mesothelioma

Significant Genes in Malignant Mesothelioma

ATM +

ATR +

BAP1 +

BARD1 +

BRCA1 +

BRCA2 +

BRIP1 +

CDK12 +

CHEK1 +

CHEK2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

MCPH1 +

MRE11A +

NBN +

NF2 +

PALB2 +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

SLX4 +

Disease Details

Synonyms
Malignant Mesothelial Neoplasm, Malignant Neoplasm of Mesothelium, MESOTHELIOMA, MALIGNANT, Malignant Tumor of Mesothelium, Malignant Neoplasm of the Mesothelium, Malignant Neoplasm c/w Malignant Mesothelioma, Malignant Mesothelial Tumor, Malignant Tumor of the Mesothelium
Parent(s)
Mesothelioma
Children
Malignant Pleural Mesothelioma, Ovarian Malignant Mesothelioma, Pericardial Malignant Mesothelioma, Diffuse Malignant Mesothelioma, and Peritoneal Malignant Mesothelioma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.