Overview

NCI Definition: A carcinoma that arises from the major or minor salivary glands. Representative examples include carcinoma ex pleomorphic adenoma, adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma. [1]

Malignant salivary gland neoplasms most frequently harbor alterations in TP53, PIK3CA, HRAS, CREBBP, and TERT [2].

Most Commonly Altered Genes in Malignant Salivary Gland Neoplasm

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in malignant salivary gland neoplasm [2].

Top Alterations in Malignant Salivary Gland Neoplasm

Significant Genes in Malignant Salivary Gland Neoplasm

ABL1 +

BRAF +

DDR2 +

EGFR +

EPHA2 +

ERBB2 +

ERBB4 +

FGFR1 +

FGFR2 +

FLT1 +

FLT4 +

FRK +

KDR +

KIT +

MAPK11 +

MLH1 +

MSH2 +

MSH6 +

PDGFRA +

PDGFRB +

PMS2 +

POLE +

RAF1 +

RET +

TEK +

TRNAK2 +

VEGFA +

VEGFB +

VEGFC +

Disease Details

Synonyms
Malignant Salivary Gland Tumor, Cancer of the Salivary Gland, Salivary Gland Cancer
Parent(s)
Malignant Head and Neck Neoplasm
Children
Malignant Parotid Gland Neoplasm, Malignant Submandibular Gland Neoplasm, Malignant Sublingual Gland Neoplasm, Epithelial-Myoepithelial Carcinoma, and Salivary Gland Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.