Associated Genetic Biomarkers
NCI Definition: A melanoma that arises from a mucosal site. 
Mucosal melanomas most frequently harbor alterations in NF1, TP53, KIT, CDKN2A, and NRAS .
CDKN2A Loss, NRAS Mutation, KIT Mutation, TP53 Mutation, and TP53 Missense are the most common alterations in mucosal melanoma .
There are 20 clinical trials for mucosal melanoma, of which 17 are open and 3 are completed or closed. Of the trials that contain mucosal melanoma as an inclusion criterion, 5 are phase 1 (5 open), 2 are phase 1/phase 2 (1 open), and 13 are phase 2 (11 open).
BRAF, PD-L1, and TYRP1 are the most frequent gene inclusion criteria for mucosal melanoma clinical trials .
Nivolumab, pembrolizumab, and ipilimumab are the most common interventions in mucosal melanoma clinical trials.
Significant Genes in Mucosal Melanoma
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.