Overview

NCI Definition: A melanoma that arises from a mucosal site. [1]

Mucosal melanomas most frequently harbor alterations in NF1, TP53, KIT, CDKN2A, and NRAS [2].

Most Commonly Altered Genes in Mucosal Melanoma

CDKN2A Loss, NRAS Mutation, KIT Mutation, TP53 Mutation, and TP53 Missense are the most common alterations in mucosal melanoma [2].

Top Alterations in Mucosal Melanoma

Significant Genes in Mucosal Melanoma

ALK +

BRAF +

CCND1 +

CDK4 +

CDK6 +

CDKN2A +

GNA11 +

GNAQ +

HRAS +

KIT +

KRAS +

MAP2K1 +

MET +

NF1 +

NRAS +

ROS1 +

Disease Details

Parent(s)
Non-Cutaneous Melanoma
Children
Mucosal Melanoma of the Head and Neck, Vulvar/Vaginal Mucosal Melanoma, Mucosal Melanoma of the Urethra, Esophageal Melanoma, and Cervical Melanoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.