Splicing factor 3b, subunit 1, 155kDa (SF3B1) is a gene that codes for part of the splicing factor 3b protein complex (Gene 2014). The complex is a member of the spliceosome and is involved in transcription and mRNA processing (Gene 2014). Spliceosome mutations are observed in MDS, chronic lymphocytic leukemia (CLL), AML, and chronic myelomonocytic leukemia (CMML), and these mutations can cause abnormal expression patterns of some genes involved in cancer pathogenesis (Chesnais et al. 2012).
Suggested Citation: Strickland, S., A. Kim. 2015. SF3B1. My Cancer Genome https://www.mycancergenome.org/content/disease/myelodysplastic-syndromes/sf3b1/?tab=0 (Updated December 7).
Last Updated: December 7, 2015