Overview

NCI Definition: A primary carcinoma of the thyroid gland composed of undifferentiated cells. The malignant cells demonstrate evidence of epithelial differentiation, either by immunohistochemistry or electron microscopic studies. Microscopically, in the majority of cases there is a mixture of spindle, epithelioid, and giant cells. The vast majority of the patients present with a rapidly enlarging neck mass. The clinical course is usually aggressive. [1]

Thyroid gland undifferentiated (anaplastic) carcinomas most frequently harbor alterations in TP53, BRAF, NRAS, CDKN2A, and PIK3CA [2].

Most Commonly Altered Genes in Thyroid Gland Undifferentiated (Anaplastic) Carcinoma

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, BRAF V600E, and BRAF Mutation are the most common alterations in thyroid gland undifferentiated (anaplastic) carcinoma [2].

Top Alterations in Thyroid Gland Undifferentiated (Anaplastic) Carcinoma

Significant Genes in Thyroid Gland Undifferentiated (Anaplastic) Carcinoma

ALK +

ARAF +

BRAF +

CRKL +

EGFR +

ERBB2 +

HRAS +

KRAS +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

NF1 +

NF2 +

NRAS +

RAF1 +

SRC +

Disease Details

Synonyms
undifferentiated carcinoma of thyroid gland, Anaplastic Thyroid Carcinoma, Undifferentiated Carcinoma of the Thyroi, Undifferentiated Thyroid Gland Carcinoma, Undifferentiated Carcinoma of the Thyroid Gland, Undifferentiated Carcinoma of Thyroid, Thyroid anaplastic carcinoma, Undifferentiated (Anaplastic) Thyroid Gland Carcinoma, Undifferentiated (Anaplastic) Thyroid Gland Cancer, Undifferentiated Carcinoma of Thyroid Gland, Anaplastic thyroid carcinoma, Undifferentiated Thyroid Tumor, Undifferentiated Thyroid Carcinoma, anaplastic thyroid cancer, undifferentiated thyroid cancer
Parent(s)
Undifferentiated Carcinoma
OncoTree Name
Anaplastic Thyroid Cancer
OncoTree Code
THAP

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.