Associated Genetic Biomarkers

Overview

NCI Definition: A primary carcinoma of the thyroid gland composed of undifferentiated cells. The malignant cells demonstrate evidence of epithelial differentiation, either by immunohistochemistry or electron microscopic studies. Microscopically, in the majority of cases there is a mixture of spindle, epithelioid, and giant cells. The vast majority of the patients present with a rapidly enlarging neck mass. The clinical course is usually aggressive. [1]

Significant Genes in Thyroid Gland Undifferentiated (Anaplastic) Carcinoma

ACBD5 +

AFAP1L2 +

ALK +

ARAF +

BRAF +

CCDC6 +

CEP43 +

CRKL +

EGFR +

ERC1 +

GOLGA5 +

HOOK3 +

HRAS +

KIAA1217 +

KIF5B +

KRAS +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

NCOA4 +

NF1 +

NF2 +

NRAS +

PPFIBP2 +

PRKAR1A +

RAF1 +

RET +

RUFY1 +

SRC +

TFG +

TRIM27 +

Disease Details

Synonyms
Undifferentiated (Anaplastic) Thyroid Gland Cancer, High-grade pleomorphic neoplasm, favor anaplastic thyroid carcinoma, Anaplastic Thyroid Carcinoma, Thyroid anaplastic carcinoma, Anaplastic thyroid carcinoma, Undifferentiated Carcinoma of Thyroid, Undifferentiated (Anaplastic) Thyroid Gland Carcinoma, undifferentiated carcinoma of thyroid gland, Undifferentiated Carcinoma of the Thyroi, Undifferentiated Thyroid Gland Carcinoma, undifferentiated thyroid cancer, Undifferentiated Carcinoma of Thyroid Gland, Undifferentiated Carcinoma of the Thyroid Gland, Undifferentiated Thyroid Carcinoma, anaplastic thyroid cancer, Undifferentiated Thyroid Tumor
Parent(s)
Undifferentiated Carcinoma
OncoTree Name
Anaplastic Thyroid Cancer
OncoTree Code
THAP

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.