Overview

Location [1]
2p23.2-p23.1
Pathways
Receptor tyrosine kinase/growth factor signaling, Kinase fusions
Protein [2]
ALK tyrosine kinase receptor
Synonyms [1]
CD246, NBLST3

ALK (anaplastic lymphoma receptor tyrosine kinase) encodes for the ALK tyrosine kinase receptor protein. ALK missense mutations, fusions, copy number gains, and/or protein expression aberrations are observed in neuroblastoma, anaplastic large cell lymphoma, colorectal cancer, inflammatory myofibroblastic tumor, non-small cell lung cancer, ovarian cancer, renal cell carcinoma, rhabdomyosarcoma, and other cancer types (PMID: 24715763; PMID: 22570254; PMID: 21076462; PMID: 22743654). Activation of ALK contributes to cell growth, proliferation, survival, and migration (PMID: 22585002).

ALK is altered in 3.21% of all cancers with non-small cell lung carcinoma, colorectal adenocarcinoma, melanoma, breast carcinoma, and uterine corpus neoplasm having the greatest prevalence of alterations [3].

ALK GENIE Cases - Top Diseases

The most common alterations in ALK are ALK Mutation (3.81%), ALK Missense (3.48%), ALK Amplification (0.12%), ALK F1174L (0.03%), and ALK P367R (0.03%) [3].

ALK GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of ALK in Diseases

Non-Small Cell Lung Carcinoma +

Inflammatory Myofibroblastic Tumor +

Malignant Solid Tumor +

Anaplastic Large Cell Lymphoma +

Non-Hodgkin Lymphoma +

Cancer +

Diffuse Large B-Cell Lymphoma +

Lymphoma +

B-Cell Non-Hodgkin Lymphoma +

Diffuse Large B-Cell Lymphoma, Not Otherwise Specified +

T-Cell/Histiocyte-Rich Large B-Cell Lymphoma +

Neuroblastoma +

B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma +

Double-Hit Lymphoma +

Mantle Cell Lymphoma +

Mediastinal Large B-Cell Lymphoma +

Multiple Myeloma +

Melanoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Follicular Lymphoma +

Gastric Carcinoma +

Colorectal Carcinoma +

Anaplastic Large Cell Lymphoma, ALK-Positive +

Burkitt Lymphoma +

Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation +

Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma +

High Grade B-Cell Lymphoma, Not Otherwise Specified +

Intravascular Large B-Cell Lymphoma +

Lymphomatoid Granulomatosis +

Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type +

Transformed Lymphoma +

Malignant Neoplasm +

Small Intestinal Carcinoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Lung Carcinoma +

Esophageal Carcinoma +

Thyroid Gland Carcinoma +

Mature B-Cell Non-Hodgkin Lymphoma +

Glioblastoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

Hepatocellular Carcinoma +

Breast Carcinoma +

Pancreatic Adenocarcinoma +

Cholangiocarcinoma +

Pancreatic Carcinoma +

ALK-Positive Large B-Cell Lymphoma +

Angioimmunoblastic T-Cell Lymphoma +

Central Nervous System Neoplasm +

Enteropathy-Associated T-Cell Lymphoma +

Extranodal Marginal Zone Lymphoma Of Mucosa-Associated Lymphoid Tissue +

Grade 3b Follicular Lymphoma +

Hepatosplenic T-Cell Lymphoma +

Histiocytic And Dendritic Cell Neoplasm +

Hodgkin Lymphoma +

Lymphoblastic Lymphoma +

Mature B-Cell Lymphoma/Leukemia +

Mature T-Cell And NK-Cell Lymphoma/Leukemia +

Mycosis Fungoides +

Nodal Marginal Zone Lymphoma +

Peripheral T-Cell Lymphoma, NOS +

Primary Central Nervous System Lymphoma +

Primary Effusion Lymphoma +

Sezary Syndrome +

Splenic Marginal Zone Lymphoma +

Triple-Hit Lymphoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.