Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
1p36.11
Synonyms [1]
MRD14, CSS2, P270, BM029, hELD, BAF250, ELD, OSA1, SMARCF1, hOSA1, B120, C1orf4, BAF250a

AT rich interactive domain 1A (SWI-like) (ARID1A) is a gene that encodes a protein that is included in the SWI/SNF family and functions in the transcriptional activation of genes. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift insertions and deletions, and in-frame insertions and deletions are observed in cancers such as biliary tract cancers, endometrial cancer, and intestinal cancer.

Significance of ARID1A in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Prostate Carcinoma +

Breast Carcinoma +

Ovarian Carcinoma +

Primary Peritoneal Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Cervical Carcinoma +

Colorectal Carcinoma +

Endometrial Carcinoma +

Endometrial Endometrioid Adenocarcinoma +

Fallopian Tube Carcinoma +

Non-Hodgkin Lymphoma +

Ovarian Clear Cell Adenocarcinoma +

Small Cell Lung Carcinoma +

Urothelial Carcinoma +

Bladder Urothelial Carcinoma +

Diffuse Large B-Cell Lymphoma +

Gastrointestinal Stromal Tumor +

Head And Neck Squamous Cell Carcinoma +

Malignant Ovarian Clear Cell Tumor +

Malignant Ovarian Epithelial Tumor +

Melanoma +

Non-Small Cell Lung Carcinoma +

Ovarian Endometrioid Adenocarcinoma +

Pancreatic Carcinoma +

Soft Tissue Sarcoma +

Ampulla Of Vater Carcinoma +

Anal Carcinoma +

Biliary Tract Carcinoma +

Bladder Carcinoma +

Cancer +

Cervical Adenocarcinoma +

Cervical Squamous Cell Carcinoma +

Cholangiocarcinoma +

Clear Cell Renal Cell Carcinoma +

Endometrial Clear Cell Adenocarcinoma +

Epithelioid Sarcoma +

Esophageal Adenocarcinoma +

Esophageal Carcinoma +

Fallopian Tube Clear Cell Adenocarcinoma +

Follicular Lymphoma +

Gastric Adenocarcinoma +

Gastric Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Leiomyosarcoma +

Lymphoma +

Malignant Esophagogastric Neoplasm +

Malignant Female Reproductive System Neoplasm +

Malignant Gastric Neoplasm +

Malignant Intestinal Neoplasm +

Malignant Ovarian Endometrioid Tumor +

Malignant Small Intestinal Neoplasm +

Malignant Soft Tissue Neoplasm +

Mantle Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Osteosarcoma +

Ovarian Carcinosarcoma +

Ovarian Small Cell Carcinoma, Hypercalcemic Type +

Pancreatic Adenocarcinoma +

Penile Carcinoma +

Peritoneal Mesothelioma +

Pleural Mesothelioma +

Primary Peritoneal Clear Cell Carcinoma +

Renal Pelvis Urothelial Carcinoma +

Rhabdoid Tumor +

Sarcomatoid Carcinoma +

Synovial Sarcoma +

Ureter Urothelial Carcinoma +

Urethral Urothelial Carcinoma +

Uterine Corpus Carcinosarcoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.