Biomarkers /
ARID1A
Overview
AT rich interactive domain 1A (SWI-like) (ARID1A) is a gene that encodes a protein that is included in the SWI/SNF family and functions in the transcriptional activation of genes. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift insertions and deletions, and in-frame insertions and deletions are observed in cancers such as biliary tract cancers, endometrial cancer, and intestinal cancer.
ARID1A is altered in 8.77% of all cancers with endometrial endometrioid adenocarcinoma, lung adenocarcinoma, colon adenocarcinoma, bladder urothelial carcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].
The most common alterations in ARID1A are ARID1A Mutation (5.58%), ARID1A Missense (2.93%), ARID1A Nonsense (2.61%), ARID1A Loss (0.23%), and ARID1A Fusion (0.20%) [3].
Clinical Trials
Significance of ARID1A in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.