Overview

Location [1]
18q21.33
Pathway
Apoptosis
Synonyms [1]
PPP1R50, Bcl-2

B-cell CLL/lymphoma 2 (BCL2) is a gene that encodes a protein that functions as an integral outer mitochondrial membrane protein. The protein inhibits the apoptotic death of cell such as lymphocytes. Fusions, missense mutations, silent mutations, frameshift deletions, and in-frame deletions are observed in cancers such as bone cancer, hematopoietic and lymphoid cancer, and stomach cancer.

Biomarker-Directed Therapies

Significance of BCL2 in Diseases

Diffuse Large B-Cell Lymphoma +

Double-Hit Lymphoma +

Diffuse Large B-Cell Lymphoma, Not Otherwise Specified +

Triple-Hit Lymphoma +

Transformed Non-Hodgkin Lymphoma +

High Grade B-Cell Lymphoma With MYC And BCL2 And/Or BCL6 Rearrangements +

High Grade B-Cell Lymphoma, Not Otherwise Specified +

T-Cell/Histiocyte-Rich Large B-Cell Lymphoma +

EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified +

Grade 3b Follicular Lymphoma +

Follicular Lymphoma +

Primary Mediastinal B-Cell Lymphoma +

Mantle Cell Lymphoma +

Burkitt Lymphoma +

Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type +

B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma +

Mediastinal Large B-Cell Lymphoma +

B-Cell Non-Hodgkin Lymphoma +

Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation +

ALK-Positive Large B-Cell Lymphoma +

Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma +

HHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified +

Marginal Zone Lymphoma +

Diffuse Large B-Cell Lymphoma Activated B-Cell Type +

Intravascular Large B-Cell Lymphoma +

Non-Hodgkin Lymphoma +

Acute Lymphoblastic Leukemia +

Chronic Lymphocytic Leukemia +

Richter Syndrome +

Burkitt Leukemia +

Hodgkin Lymphoma +

Multiple Myeloma +

Waldenstrom Macroglobulinemia +

Acute Myeloid Leukemia +

Breast Carcinoma +

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma +

Lymphomatoid Granulomatosis +

Mature B-Cell Lymphoma/Leukemia +

Primary Central Nervous System Lymphoma +

Anaplastic Large Cell Lymphoma, ALK-Positive +

Atypical Burkitt/Burkitt-Like Lymphoma +

B-Cell Acute Lymphoblastic Leukemia +

Burkitt-Like Lymphoma With 11q Aberration +

Chronic Myeloid Leukemia +

Composite Lymphoma +

EBV-Positive Mucocutaneous Ulcer +

Extranodal Marginal Zone Lymphoma Of Mucosa-Associated Lymphoid Tissue +

Grade 1 Follicular Lymphoma +

Grade 2 Follicular Lymphoma +

Grade 3 Follicular Lymphoma +

Head And Neck Squamous Cell Carcinoma +

Hematopoietic And Lymphoid Malignancy +

Indolent Non-Hodgkin Lymphoma +

Invasive Breast Carcinoma +

Large B-Cell Lymphoma With IRF4 Rearrangement +

Lymphoplasmacytic Lymphoma +

Malignant Solid Tumor +

Mature B-Cell Non-Hodgkin Lymphoma +

Mature T-Cell And NK-Cell Lymphoma/Leukemia +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Nodal Marginal Zone Lymphoma +

Ovarian Carcinoma +

Pancreatic Carcinoma +

Peripheral T-Cell Lymphoma +

Plasma Cell Leukemia +

Plasmablastic Lymphoma +

Primary Effusion Lymphoma +

Small Cell Lung Carcinoma +

Small Lymphocytic Lymphoma +

Soft Tissue Sarcoma +

Splenic Marginal Zone Lymphoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.