Overview

Location [1]
12q14.1
Pathway
Cell cycle control
Synonyms [1]
PSK-J3, CMM3

Cyclin-dependent kinase 4 (CDK4) is a gene that encodes a protein that is a member of the serine/threonine kinase family. The protein functions in the progression of the cell cycle at from G1 to S phase and the activation of RB1. Missense and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

Biomarker-Directed Therapies

Significance of CDK4 in Diseases

Liposarcoma +

Malignant Solid Tumor +

Breast Carcinoma +

Colorectal Carcinoma +

Malignant Glioma +

Melanoma +

Soft Tissue Sarcoma +

Head And Neck Squamous Cell Carcinoma +

Non-Hodgkin Lymphoma +

Non-Small Cell Lung Carcinoma +

Osteosarcoma +

Ovarian Carcinoma +

Acral Lentiginous Melanoma +

Adenocarcinoma Of The Gastroesophageal Junction +

B-Cell Non-Hodgkin Lymphoma +

Bile Duct Carcinoma +

Bladder Carcinoma +

Bronchogenic Carcinoma +

Cancer +

Cervical Carcinoma +

Chondrosarcoma +

Chordoma +

Dedifferentiated Chondrosarcoma +

Endometrial Endometrioid Adenocarcinoma +

Esophageal Carcinoma +

Esophageal Squamous Cell Carcinoma +

Fallopian Tube Carcinoma +

Gallbladder Carcinoma +

Gastric Adenocarcinoma +

Gastric Carcinoma +

Germ Cell Tumor +

Glioblastoma +

Head And Neck Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Leiomyosarcoma +

Lung Adenocarcinoma +

Lung Carcinoma +

Malignant Uterine Neoplasm +

Meningioma +

Mucosal Melanoma +

Multiple Myeloma +

Ovarian Epithelial Tumor +

Pancreatic Carcinoma +

Primary Peritoneal Carcinoma +

Prostate Carcinoma +

Squamous Cell Lung Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.