Overview

Location [1]
12q14.1
Pathway
Cell cycle control
Protein [2]
Cyclin-dependent kinase 4
Synonyms [1]
CMM3, PSK-J3

Cyclin-dependent kinase 4 (CDK4) is a gene that encodes a protein that is a member of the serine/threonine kinase family. The protein functions in the progression of the cell cycle at from G1 to S phase and the activation of RB1. Missense and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

CDK4 is altered in 2.05% of all cancers with lung adenocarcinoma, conventional glioblastoma multiforme, dedifferentiated liposarcoma, breast invasive ductal carcinoma, and glioblastoma having the greatest prevalence of alterations [3].

CDK4 GENIE Cases - Top Diseases

The most common alterations in CDK4 are CDK4 Amplification (1.94%), CDK4 Mutation (0.47%), CDK4 R24L (0.03%), CDK4 R24H (0.01%), and CDK4 G300S (0.01%) [3].

CDK4 GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of CDK4 in Diseases

Liposarcoma +

Malignant Solid Tumor +

Breast Carcinoma +

Multiple Myeloma +

Soft Tissue Sarcoma +

Non-Small Cell Lung Carcinoma +

Melanoma +

Esophageal Carcinoma +

Colorectal Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Head And Neck Squamous Cell Carcinoma +

Non-Hodgkin Lymphoma +

Acral Lentiginous Melanoma +

Glioblastoma +

Malignant Glioma +

Osteosarcoma +

Malignant Central Nervous System Neoplasm +

Gallbladder Carcinoma +

Lung Carcinoma +

Cancer +

Endometrial Carcinoma +

Malignant Uterine Corpus Neoplasm +

Squamous Cell Lung Carcinoma +

Malignant Uterine Neoplasm +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Bladder Carcinoma +

Ovarian Carcinoma +

Prostate Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Bile Duct Carcinoma +

Bronchioloalveolar Carcinoma +

Bronchogenic Carcinoma +

Cervical Carcinoma +

Cholangiocarcinoma +

Chondrosarcoma +

Chordoma +

Clear Cell Renal Cell Carcinoma +

Dedifferentiated Chondrosarcoma +

Esophageal Squamous Cell Carcinoma +

Fallopian Tube Carcinoma +

Gastric Adenocarcinoma +

Gastric Carcinoma +

Germ Cell Tumor +

Head And Neck Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Mesothelioma +

Neuroblastoma +

Primary Peritoneal Carcinoma +

Uveal Melanoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20171026. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.