Biomarkers /
CDK4
Overview
Cyclin-dependent kinase 4 (CDK4) is a gene that encodes a protein that is a member of the serine/threonine kinase family. The protein functions in the progression of the cell cycle at from G1 to S phase and the activation of RB1. Missense and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.
Biomarker-Directed Therapies
Clinical Trials
Significance of CDK4 in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.