Overview

Location [1]
7q21.2
Pathway
Cell cycle control
Synonyms [1]
MCPH12, PLSTIRE

Cyclin-dependent kinase 4 (CDK6) is a gene that encodes a protein that is a member of the cyclin-dependent protein kinase family. The protein functions in the progression of the cell cycle at from G1 to S phase and the regulation of RB1. Fusions, missense, nonsense, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

Significance of CDK6 in Diseases

Malignant Solid Tumor +

Medulloblastoma +

Malignant Glioma +

Medulloblastoma, Non-WNT/Non-SHH +

Breast Carcinoma +

Central Nervous System Embryonal Neoplasm +

Central Nervous System Ganglioneuroblastoma +

Central Nervous System Neuroblastoma +

Colorectal Carcinoma +

Desmoplastic/Nodular Medulloblastoma +

Glioblastoma +

Head And Neck Squamous Cell Carcinoma +

Large Cell/Anaplastic Medulloblastoma +

Medulloblastoma With Extensive Nodularity +

Medulloblastoma, SHH-Activated +

Medulloblastoma, WNT-Activated +

Medulloepithelioma +

Melanoma +

Non-Hodgkin Lymphoma +

Ovarian Carcinoma +

Soft Tissue Sarcoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Anaplastic Astrocytoma +

Anaplastic Astrocytoma, IDH-Mutant +

Anaplastic Ependymoma +

Anaplastic Oligodendroglioma +

Anaplastic Oligodendroglioma, IDH-Mutant And 1p/19q-Codeleted +

Anaplastic Pleomorphic Xanthoastrocytoma +

Atypical Teratoid/Rhabdoid Tumor +

B-Cell Non-Hodgkin Lymphoma +

Bile Duct Carcinoma +

Bladder Carcinoma +

Bronchogenic Carcinoma +

Cancer +

Cervical Carcinoma +

Chondrosarcoma +

Chordoma +

Dedifferentiated Chondrosarcoma +

Diffuse Glioma +

Diffuse Midline Glioma, H3 K27M-Mutant +

Embryonal Tumor With Multilayered Rosettes, C19MC-Altered +

Embryonal Tumor With Multilayered Rosettes, Not Otherwise Specified +

Endometrial Endometrioid Adenocarcinoma +

Ependymoma +

Ependymoma, RELA Fusion-Positive +

Esophageal Carcinoma +

Esophageal Squamous Cell Carcinoma +

Fallopian Tube Carcinoma +

Gallbladder Carcinoma +

Gastric Adenocarcinoma +

Gastric Carcinoma +

Germ Cell Tumor +

Head And Neck Carcinoma +

High-Grade Glioma, NOS +

Histiocytic And Dendritic Cell Neoplasm +

Lung Carcinoma +

Malignant Uterine Neoplasm +

Meningioma +

Mucosal Melanoma +

Multiple Myeloma +

Non-Small Cell Lung Carcinoma +

Osteosarcoma +

Ovarian Epithelial Tumor +

Pancreatic Carcinoma +

Pineoblastoma +

Primary Peritoneal Carcinoma +

Squamous Cell Lung Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.