Overview

Location [1]
1p34.3
Protein [2]
Granulocyte colony-stimulating factor receptor
Synonyms [1]
CD114, SCN7, GCSFR

Colony stimulating factor 3 receptor (CSF3R) is a gene that encodes the receptor associated with colony stimulating factor 3, which is a member of the family of cytokine receptors. Missense mutations, nonsense mutations, silent mutations, and frameshift mutations are observed in cancers such as colorectal cancer, leukemias, lung cancer, skin cancer, and stomach cancer.

CSF3R is altered in 1.33% of all cancers with lung adenocarcinoma, colon adenocarcinoma, cutaneous melanoma, breast invasive ductal carcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

CSF3R GENIE Cases - Top Diseases

The most common alterations in CSF3R are CSF3R Mutation (1.25%), CSF3R Amplification (0.07%), CSF3R S469Afs*22 (0.06%), CSF3R Loss (0.02%), and CSF3R T618I (0.02%) [3].

CSF3R GENIE Cases - Top Alterations

Significance of CSF3R in Diseases

Acute Myeloid Leukemia +

Myeloid Neoplasm +

Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative +

Chronic Neutrophilic Leukemia +

Myelodysplastic Syndrome With Excess Blasts-2 +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.