Overview

Location [1]
4q31.3
Protein [2]
F-box/WD repeat-containing protein 7
Synonyms [1]
hCdc4, CDC4, FBW7, SEL-10, SEL10, FBX30, FBXO30, FBW6, AGO, hAgo, FBXW6

F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (FBXW7) is a gene that encodes a member of the F-box protein family. Missense, nonsense, silent, and frameshift insertions and deletions are observed in cancers such as breast cancer, colorectal cancer, leukemias, lung cancer, and skin cancer.

FBXW7 is altered in 2.82% of all cancers with colon adenocarcinoma, rectal adenocarcinoma, lung adenocarcinoma, colorectal adenocarcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

FBXW7 GENIE Cases - Top Diseases

The most common alterations in FBXW7 are FBXW7 Mutation (4.17%), FBXW7 R465C (0.39%), FBXW7 R465H (0.32%), FBXW7 R505C (0.29%), and FBXW7 R479Q (0.23%) [3].

FBXW7 GENIE Cases - Top Alterations

Significance of FBXW7 in Diseases

Malignant Solid Tumor +

Colon Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Lymphoma +

Cholangiocarcinoma +

Breast Carcinoma +

Soft Tissue Sarcoma +

Acute Myeloid Leukemia +

Gastrointestinal Stromal Tumor +

Leiomyosarcoma +

Multiple Myeloma +

Myelodysplastic Syndrome With Excess Blasts-2 +

Myeloid Neoplasm +

Osteosarcoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.