Biomarkers /
FGFR2
Overview
FGFR2 (fibroblast growth factor receptor 2 gene) encodes the fibroblast growth factor receptor 2 protein, a receptor tyrosine kinase. FGFR2 and other FGFR TKs play crucial roles in development and have been shown in cancers to be deregulated by amplification, point mutation, or translocation (PMID: 20094046). Amplification or activation of FGFR2 has been reported in breast cancer and gastric cancer (PMID: 22731805). FGFR2 mutations have been observed in endometrial cancer and breast cancer (PMID: 18552176; PMID: 22731805; PMID: 23527311).
FGFR2 is altered in 2.02% of all cancers with endometrial endometrioid adenocarcinoma, breast invasive ductal carcinoma, cutaneous melanoma, colon adenocarcinoma, and lung adenocarcinoma having the greatest prevalence of alterations [3].
The most common alterations in FGFR2 are FGFR2 Mutation (1.49%), FGFR2 Amplification (0.37%), FGFR2 Fusion (0.32%), FGFR2 S252W (0.17%), and FGFR2 Loss (0.11%) [3].
Biomarker-Directed Therapies
Clinical Trials
Significance of FGFR2 in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.