Overview

Location [1]
10q26.13
Pathways
Receptor tyrosine kinase/growth factor signaling, Kinase fusions
Protein [2]
Fibroblast growth factor receptor 2
Synonyms [1]
BEK, CEK3, KGFR, ECT1, BFR-1, CD332, K-SAM, JWS, CFD1, TK14, TK25, BBDS

FGFR2 (fibroblast growth factor receptor 2 gene) encodes the fibroblast growth factor receptor 2 protein, a receptor tyrosine kinase. FGFR2 and other FGFR TKs play crucial roles in development and have been shown in cancers to be deregulated by amplification, point mutation, or translocation (PMID: 20094046). Amplification or activation of FGFR2 has been reported in breast cancer and gastric cancer (PMID: 22731805). FGFR2 mutations have been observed in endometrial cancer and breast cancer (PMID: 18552176; PMID: 22731805; PMID: 23527311).

 

FGFR2 is altered in 2.02% of all cancers with uterine corpus neoplasm, melanoma, breast carcinoma, colorectal adenocarcinoma, and non-small cell lung carcinoma having the greatest prevalence of alterations [3].

FGFR2 GENIE Cases - Top Diseases

The most common alterations in FGFR2 are FGFR2 Mutation (1.99%), FGFR2 Amplification (0.34%), FGFR2 S252W (0.17%), FGFR2 N549K (0.09%), and FGFR2 C382R (0.09%) [3].

FGFR2 GENIE Cases - Top Alterations

Significance of FGFR2 in Diseases

Malignant Solid Tumor +

Urothelial Carcinoma +

Non-Small Cell Lung Carcinoma +

Cholangiocarcinoma +

Breast Carcinoma +

Multiple Myeloma +

Gastric Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Cancer +

Head And Neck Squamous Cell Carcinoma +

Bladder Carcinoma +

Esophageal Carcinoma +

Squamous Cell Lung Carcinoma +

Lymphoma +

Glioblastoma +

Anaplastic Astrocytoma +

Pancreatic Carcinoma +

Non-Hodgkin Lymphoma +

Endometrioid Adenocarcinoma +

Endometrial Carcinoma +

Melanoma +

Nasal Cavity And Paranasal Sinus Carcinoma +

Intrahepatic Cholangiocarcinoma +

Gastric Adenocarcinoma +

Anaplastic Oligodendroglioma +

Ovarian Carcinoma +

Head And Neck Carcinoma +

Colorectal Carcinoma +

Small Cell Lung Carcinoma +

Glioma +

Sarcoma +

Gastrointestinal Stromal Tumor +

B-Cell Acute Lymphoblastic Leukemia +

B-Cell Non-Hodgkin Lymphoma +

Extrahepatic Cholangiocarcinoma +

Hepatobiliary Neoplasm +

Histiocytic And Dendritic Cell Neoplasm +

Lip And Oral Cavity Carcinoma +

Malignant Laryngeal Neoplasm +

Malignant Salivary Gland Neoplasm +

Myeloproliferative Neoplasm +

Nasopharyngeal Carcinoma +

Oropharyngeal Carcinoma +

Transitional Cell Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.