Associated Genetic Biomarkers
Associated Diseases
Associated Pathways


Location [1]
Kinase fusions, Receptor tyrosine kinase/growth factor signaling
Protein [2]
Fibroblast growth factor receptor 2
Synonyms [1]

FGFR2 (fibroblast growth factor receptor 2 gene) encodes the fibroblast growth factor receptor 2 protein, a receptor tyrosine kinase. FGFR2 and other FGFR TKs play crucial roles in development and have been shown in cancers to be deregulated by amplification, point mutation, or translocation (PMID: 20094046). Amplification or activation of FGFR2 has been reported in breast cancer and gastric cancer (PMID: 22731805). FGFR2 mutations have been observed in endometrial cancer and breast cancer (PMID: 18552176; PMID: 22731805; PMID: 23527311).


FGFR2 is altered in 2.02% of all cancers with endometrial endometrioid adenocarcinoma, breast invasive ductal carcinoma, cutaneous melanoma, colon adenocarcinoma, and lung adenocarcinoma having the greatest prevalence of alterations [3].

FGFR2 GENIE Cases - Top Diseases

The most common alterations in FGFR2 are FGFR2 Mutation (1.49%), FGFR2 Amplification (0.37%), FGFR2 Fusion (0.32%), FGFR2 S252W (0.17%), and FGFR2 Loss (0.11%) [3].

FGFR2 GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of FGFR2 in Diseases

Cholangiocarcinoma +

Malignant Solid Tumor +

Urothelial Carcinoma +

Breast Carcinoma +

Non-Small Cell Lung Carcinoma +

Acute Lymphoblastic Leukemia +

Adenocarcinoma Of The Gastroesophageal Junction +

Gastric Carcinoma +

B-Cell Acute Lymphoblastic Leukemia +

Intrahepatic Cholangiocarcinoma +

Gastric Adenocarcinoma +

Bladder Carcinoma +

Cancer +

Endometrial Carcinoma +

Colorectal Carcinoma +

Squamous Cell Lung Carcinoma +

Sarcoma +

Pancreatic Carcinoma +

Acute Myeloid Leukemia +

Multiple Myeloma +

Melanoma +

Esophageal Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Head And Neck Carcinoma +

Glioblastoma +

Non-Hodgkin Lymphoma +

Ovarian Carcinoma +

Anaplastic Astrocytoma +

Gastrointestinal Stromal Tumor +

Mixed Phenotype Acute Leukemia +

Myelodysplastic Syndromes +

Low-Grade Neuroepithelial Tumor, NOS +

Endometrioid Adenocarcinoma +

Bile Duct Carcinoma +

Malignant Uterine Neoplasm +

Malignant Hepatobiliary Neoplasm +

Hepatobiliary Neoplasm +

Anaplastic Oligodendroglioma +

Nasal Cavity And Paranasal Sinus Carcinoma +

Transitional Cell Carcinoma +

Ganglioglioma +

Oropharyngeal Carcinoma +

Oropharyngeal Squamous Cell Carcinoma +

Bladder Urothelial Carcinoma +

Lip And Oral Cavity Carcinoma +

Oral Cavity Carcinoma +

Oral Cavity Squamous Cell Carcinoma +

Cervical Carcinoma +

Esophageal Squamous Cell Carcinoma +

Laryngeal Squamous Cell Carcinoma +

Malignant Laryngeal Neoplasm +

Neuronal And Mixed Neuronal-Glial Tumors +

Low Grade Glioma +

Malignant Salivary Gland Neoplasm +

Diffuse Glioma +

B-Cell Non-Hodgkin Lymphoma +

Invasive Breast Carcinoma +

Lung Carcinoma +

Small Cell Lung Carcinoma +

Glioma +

Lymphoma +

Astrocytic Tumor +

Gallbladder Carcinoma +

Extrahepatic Cholangiocarcinoma +

Lymphocytic Neoplasm +

Soft Tissue Sarcoma +

Pancreatic Adenocarcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Myeloproliferative Neoplasm +

Myeloid Neoplasm +

B-Cell Lymphoblastic Lymphoma +

Bronchogenic Carcinoma +

Chronic Myeloid Leukemia +

Chronic Myelomonocytic Leukemia +

Dysembryoplastic Neuroepithelial Tumor +

Gangliocytoma +

Hypopharyngeal Squamous Cell Carcinoma +

Lymphoblastic Lymphoma +

Mixed Phenotype Acute Leukemia, B/Myeloid, NOS +

Mixed Phenotype Acute Leukemia, T/Myeloid, NOS +

Nasopharyngeal Carcinoma +

Non-Muscle Invasive Bladder Carcinoma +

Perihilar Intrahepatic Cholangiocarcinoma +

Pilocytic Astrocytoma +

Pilomyxoid Astrocytoma +

Secondary Acute Myeloid Leukemia +

T-Cell Acute Lymphoblastic Leukemia +

T-Cell Lymphoblastic Lymphoma +

Therapy-Related Acute Myeloid Leukemia +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.