Associated Genetic Biomarkers
Associated Diseases
Associated Pathways

Overview

Location [1]
10q26.13
Pathways
Kinase fusions, Receptor tyrosine kinase/growth factor signaling
Synonyms [1]
ECT1, TK25, KGFR, BBDS, BFR-1, CD332, CEK3, BEK, CFD1, JWS, TK14, K-SAM

FGFR2 (fibroblast growth factor receptor 2 gene) encodes the fibroblast growth factor receptor 2 protein, a receptor tyrosine kinase. FGFR2 and other FGFR TKs play crucial roles in development and have been shown in cancers to be deregulated by amplification, point mutation, or translocation (PMID: 20094046). Amplification or activation of FGFR2 has been reported in breast cancer and gastric cancer (PMID: 22731805). FGFR2 mutations have been observed in endometrial cancer and breast cancer (PMID: 18552176; PMID: 22731805; PMID: 23527311).

 

Biomarker-Directed Therapies

Significance of FGFR2 in Diseases

Cholangiocarcinoma +

Malignant Solid Tumor +

Urothelial Carcinoma +

Breast Carcinoma +

Non-Small Cell Lung Carcinoma +

Acute Lymphoblastic Leukemia +

Adenocarcinoma Of The Gastroesophageal Junction +

Gastric Carcinoma +

B-Cell Acute Lymphoblastic Leukemia +

Bladder Carcinoma +

Cancer +

Gastric Adenocarcinoma +

Intrahepatic Cholangiocarcinoma +

Acute Myeloid Leukemia +

Colorectal Carcinoma +

Endometrial Carcinoma +

Multiple Myeloma +

Pancreatic Carcinoma +

Sarcoma +

Squamous Cell Lung Carcinoma +

Anaplastic Astrocytoma +

Esophageal Carcinoma +

Gastrointestinal Stromal Tumor +

Glioblastoma +

Head And Neck Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Melanoma +

Mixed Phenotype Acute Leukemia +

Myelodysplastic Syndromes +

Non-Hodgkin Lymphoma +

Ovarian Carcinoma +

Anaplastic Oligodendroglioma +

Astrocytic Tumor +

B-Cell Lymphoblastic Lymphoma +

B-Cell Non-Hodgkin Lymphoma +

Bile Duct Carcinoma +

Bladder Urothelial Carcinoma +

Bronchogenic Carcinoma +

Cervical Carcinoma +

Chronic Myeloid Leukemia +

Chronic Myelomonocytic Leukemia +

Diffuse Glioma +

Dysembryoplastic Neuroepithelial Tumor +

Endometrioid Adenocarcinoma +

Esophageal Squamous Cell Carcinoma +

Extrahepatic Cholangiocarcinoma +

Gallbladder Carcinoma +

Gangliocytoma +

Ganglioglioma +

Glioma +

Hepatobiliary Neoplasm +

Histiocytic And Dendritic Cell Neoplasm +

Hypopharyngeal Squamous Cell Carcinoma +

Invasive Breast Carcinoma +

Laryngeal Squamous Cell Carcinoma +

Lip And Oral Cavity Carcinoma +

Low Grade Glioma +

Low-Grade Neuroepithelial Tumor, NOS +

Lung Carcinoma +

Lymphoblastic Lymphoma +

Lymphocytic Neoplasm +

Lymphoma +

Malignant Hepatobiliary Neoplasm +

Malignant Laryngeal Neoplasm +

Malignant Salivary Gland Neoplasm +

Malignant Uterine Neoplasm +

Mixed Phenotype Acute Leukemia, B/Myeloid, NOS +

Mixed Phenotype Acute Leukemia, T/Myeloid, NOS +

Myeloid Neoplasm +

Myeloproliferative Neoplasm +

Nasal Cavity And Paranasal Sinus Carcinoma +

Nasopharyngeal Carcinoma +

Neuronal And Mixed Neuronal-Glial Tumors +

Non-Muscle Invasive Bladder Carcinoma +

Oral Cavity Carcinoma +

Oral Cavity Squamous Cell Carcinoma +

Oropharyngeal Carcinoma +

Oropharyngeal Squamous Cell Carcinoma +

Pancreatic Adenocarcinoma +

Perihilar Intrahepatic Cholangiocarcinoma +

Pilocytic Astrocytoma +

Pilomyxoid Astrocytoma +

Secondary Acute Myeloid Leukemia +

Small Cell Lung Carcinoma +

Soft Tissue Sarcoma +

T-Cell Acute Lymphoblastic Leukemia +

T-Cell Lymphoblastic Lymphoma +

Therapy-Related Acute Myeloid Leukemia +

Transitional Cell Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.