Overview

Location [1]
5q35.2
Pathway
Receptor tyrosine kinase/growth factor signaling
Synonyms [1]
JTK2, TKF, CD334

Fibroblast growth factor receptor 4 (FGFR4) is a gene that encodes a protein with a tyrosine kinase domain and three immunoglobulin-like domains. The protein functions in mitogenesis and differentiation. Missense mutations, nonsense mutations, silent mutations, and frameshift insertions and deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

Significance of FGFR4 in Diseases

Malignant Solid Tumor +

Acute Lymphoblastic Leukemia +

Urothelial Carcinoma +

B-Cell Acute Lymphoblastic Leukemia +

Cholangiocarcinoma +

Acute Myeloid Leukemia +

Breast Carcinoma +

Cancer +

Gastric Carcinoma +

Mixed Phenotype Acute Leukemia +

Multiple Myeloma +

Myelodysplastic Syndromes +

Non-Hodgkin Lymphoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Anaplastic Astrocytoma +

Anaplastic Oligodendroglioma +

B-Cell Lymphoblastic Lymphoma +

Chronic Myeloid Leukemia +

Chronic Myelomonocytic Leukemia +

Endometrial Carcinoma +

Extrahepatic Cholangiocarcinoma +

Gastrointestinal Stromal Tumor +

Glioblastoma +

Histiocytic And Dendritic Cell Neoplasm +

Intrahepatic Cholangiocarcinoma +

Invasive Breast Carcinoma +

Lymphoblastic Lymphoma +

Lymphocytic Neoplasm +

Mixed Phenotype Acute Leukemia, B/Myeloid, NOS +

Mixed Phenotype Acute Leukemia, T/Myeloid, NOS +

Myeloid Neoplasm +

Myeloproliferative Neoplasm +

Non-Muscle Invasive Bladder Carcinoma +

Non-Small Cell Lung Carcinoma +

Sarcoma +

Secondary Acute Myeloid Leukemia +

Squamous Cell Lung Carcinoma +

T-Cell Acute Lymphoblastic Leukemia +

T-Cell Lymphoblastic Lymphoma +

Therapy-Related Acute Myeloid Leukemia +

Transitional Cell Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.