Overview

Location [1]
1q42.12
Synonyms [1]
H3.3A, H3F3

H3 histone, family 3A (H3F3A) is a gene that encodes a histone, the nuclear proteins responsible for the nucleosome structure of the chromosomal fiber. Missense mutations are observed in cancers such as bone cancer, central nervous system cancers, and endometrial cancer.

Significance of H3F3A in Diseases

Diffuse Midline Glioma, H3 K27M-Mutant +

Diffuse Intrinsic Pontine Glioma +

Malignant Glioma +

Anaplastic Astrocytoma +

Atypical Teratoid/Rhabdoid Tumor +

Diffuse Glioma +

Ependymoma +

Glioblastoma +

Glioma +

Medulloblastoma +

Anaplastic Pleomorphic Xanthoastrocytoma +

Central Nervous System Embryonal Neoplasm +

Embryonal Tumor With Multilayered Rosettes, C19MC-Altered +

Embryonal Tumor With Multilayered Rosettes, Not Otherwise Specified +

Gliomatosis Cerebri +

Gliosarcoma +

High-Grade Glioma, NOS +

Primitive Neuroectodermal Tumor +

Anaplastic Astrocytoma, IDH-Mutant +

Anaplastic Ependymoma +

Anaplastic Oligoastrocytoma +

Anaplastic Oligodendroglioma +

Anaplastic Oligodendroglioma, IDH-Mutant And 1p/19q-Codeleted +

Atypical Meningioma +

Central Nervous System Ganglioneuroblastoma +

Central Nervous System Neuroblastoma +

Central Nervous System Sarcoma +

Choroid Plexus Neoplasm +

Ependymal Tumor +

Ependymoma, RELA Fusion-Positive +

Fibrillary Astrocytoma +

Malignant Central Nervous System Germ Cell Tumor +

Malignant Central Nervous System Neoplasm +

Malignant Peripheral Nerve Sheath Tumor +

Malignant Primary Brain Neoplasm +

Medulloblastoma, Non-WNT/Non-SHH +

Medulloblastoma, SHH-Activated +

Medulloblastoma, WNT-Activated +

Medulloepithelioma +

Pineal Region Neoplasm +

Pineoblastoma +

Pineocytoma +

Pleomorphic Xanthoastrocytoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.