Biomarkers /
H3F3A
Overview
H3 histone, family 3A (H3F3A) is a gene that encodes a histone, the nuclear proteins responsible for the nucleosome structure of the chromosomal fiber. Missense mutations are observed in cancers such as bone cancer, central nervous system cancers, and endometrial cancer.
Clinical Trials
Significance of H3F3A in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.