Location [1]
Synonyms [1]
H3F3, H3.3A

H3 histone, family 3A (H3F3A) is a gene that encodes a histone, the nuclear proteins responsible for the nucleosome structure of the chromosomal fiber. Missense mutations are observed in cancers such as bone cancer, central nervous system cancers, and endometrial cancer.

H3F3A is altered in 0.71% of all cancers with breast invasive ductal carcinoma, diffuse intrinsic pontine glioma, conventional glioblastoma multiforme, colon adenocarcinoma, and glioblastoma having the greatest prevalence of alterations [3].

H3F3A GENIE Cases - Top Diseases

The most common alterations in H3F3A are H3F3A Mutation (0.49%), H3F3A K28M (0.21%), H3F3A Amplification (0.25%), H3F3A G35R (0.04%), and H3F3A G35W (0.02%) [3].

H3F3A GENIE Cases - Top Alterations

Significance of H3F3A in Diseases

Diffuse Midline Glioma, H3 K27M-Mutant +

Diffuse Intrinsic Pontine Glioma +

Malignant Glioma +

Diffuse Glioma +

Glioma +

Anaplastic Astrocytoma +

Glioblastoma +

Medulloblastoma +

Atypical Teratoid/Rhabdoid Tumor +

Ependymoma +

High-Grade Glioma, NOS +

Central Nervous System Embryonal Neoplasm +

Primitive Neuroectodermal Tumor +

Anaplastic Pleomorphic Xanthoastrocytoma +

Embryonal Tumor With Multilayered Rosettes, C19MC-Altered +

Embryonal Tumor With Multilayered Rosettes, Not Otherwise Specified +

Gliomatosis Cerebri +

Gliosarcoma +

Anaplastic Ependymoma +

Malignant Central Nervous System Neoplasm +

Ependymal Tumor +

Anaplastic Astrocytoma, IDH-Mutant +

Anaplastic Oligoastrocytoma +

Anaplastic Oligodendroglioma +

Anaplastic Oligodendroglioma, IDH-Mutant And 1p/19q-Codeleted +

Atypical Meningioma +

Central Nervous System Ganglioneuroblastoma +

Central Nervous System Neuroblastoma +

Central Nervous System Sarcoma +

Choroid Plexus Neoplasm +

Ependymoma, RELA Fusion-Positive +

Fibrillary Astrocytoma +

Malignant Central Nervous System Germ Cell Tumor +

Malignant Peripheral Nerve Sheath Tumor +

Malignant Primary Brain Neoplasm +

Medulloblastoma, Non-WNT/Non-SHH +

Medulloblastoma, SHH-Activated +

Medulloblastoma, WNT-Activated +

Medulloepithelioma +

Pineal Region Neoplasm +

Pineoblastoma +

Pineocytoma +

Pleomorphic Xanthoastrocytoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.