Overview

Location [1]
7q31.2
Pathway
Receptor tyrosine kinase/growth factor signaling
Synonyms [1]
AUTS9, DFNB97, RCCP2, HGFR, c-Met

MET (MET proto-oncogene, receptor tyrosine kinase) encodes the hepatocyte growth factor receptor protein. Germline mutations in the tyrosine kinase domain of MET occur in 100% of hereditary papillary renal cell carcinoma (PMID: 9140397). Somatic MET mutations and/or amplifications have been observed in sporadic papillary renal cell carcinoma, head and neck squamous cell carcinoma (PMID: 10734314), childhood hepatocellular carcinoma (PMID: 9927037), lung cancer (PMID: 14559814; PMID: 17463250), gastric cancer (PMID: 10223227), esophageal cancer (PMID: 16186806), colorectal cancer (PMID: 10343196), gliomas (PMID: 18077431), and clear cell ovarian cancer (PMID: 21478826). In the context of malignancy, aberrant signaling through the MET receptor promotes pleiotrophic effects including growth, survival, invasion, migration, angiogenesis and metastasis (Birchmeier et al. 2003; Peruzzi and Bottaro 2006).

Biomarker-Directed Therapies

Significance of MET in Diseases

Non-Small Cell Lung Carcinoma +

Malignant Solid Tumor +

Adenocarcinoma Of The Gastroesophageal Junction +

Breast Carcinoma +

Colorectal Carcinoma +

Gastric Adenocarcinoma +

Hepatocellular Carcinoma +

Melanoma +

Cancer +

Gastric Carcinoma +

Squamous Cell Lung Carcinoma +

Bladder Carcinoma +

Glioblastoma +

Head And Neck Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Lymphoma +

Prostate Carcinoma +

Colorectal Adenocarcinoma +

Endometrial Carcinoma +

Multiple Myeloma +

Ovarian Carcinoma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Renal Cell Carcinoma +

Soft Tissue Sarcoma +

Urothelial Carcinoma +

Adrenal Cortex Carcinoma +

Alveolar Soft Part Sarcoma +

Anaplastic Astrocytoma +

B-Cell Non-Hodgkin Lymphoma +

Bile Duct Carcinoma +

Bronchogenic Carcinoma +

Cervical Carcinoma +

Cervical Squamous Cell Carcinoma +

Cholangiocarcinoma +

Clear Cell Renal Cell Carcinoma +

Clear Cell Sarcoma Of Soft Tissue +

Diffuse Intrinsic Pontine Glioma +

Esophageal Carcinoma +

Esophageal Squamous Cell Carcinoma +

Ewing Sarcoma +

Gallbladder Carcinoma +

Glioma +

Gliosarcoma +

Hepatoblastoma +

High Grade Ovarian Serous Adenocarcinoma +

Lung Adenocarcinoma +

Lung Carcinoma +

Malignant Uterine Neoplasm +

Medulloblastoma +

Mesothelioma +

Mucosal Melanoma +

Non-Squamous Non-Small Cell Lung Carcinoma +

Osteosarcoma +

Papillary Renal Cell Carcinoma +

Rhabdomyosarcoma +

Sarcoma +

Small Intestinal Adenocarcinoma +

Thyroid Gland Medullary Carcinoma +

Wilms Tumor +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.