Associated Genetic Biomarkers
Associated Diseases
Associated Pathways

Overview

Location [1]
7q31.2
Pathway
Receptor tyrosine kinase/growth factor signaling
Protein [2]
Hepatocyte growth factor receptor
Synonyms [1]
RCCP2, DFNB97, c-Met, HGFR, AUTS9

MET (MET proto-oncogene, receptor tyrosine kinase) encodes the hepatocyte growth factor receptor protein. Germline mutations in the tyrosine kinase domain of MET occur in 100% of hereditary papillary renal cell carcinoma (PMID: 9140397). Somatic MET mutations and/or amplifications have been observed in sporadic papillary renal cell carcinoma, head and neck squamous cell carcinoma (PMID: 10734314), childhood hepatocellular carcinoma (PMID: 9927037), lung cancer (PMID: 14559814; PMID: 17463250), gastric cancer (PMID: 10223227), esophageal cancer (PMID: 16186806), colorectal cancer (PMID: 10343196), gliomas (PMID: 18077431), and clear cell ovarian cancer (PMID: 21478826). In the context of malignancy, aberrant signaling through the MET receptor promotes pleiotrophic effects including growth, survival, invasion, migration, angiogenesis and metastasis (Birchmeier et al. 2003; Peruzzi and Bottaro 2006).

MET is altered in 2.23% of all cancers with lung adenocarcinoma, colon adenocarcinoma, cutaneous melanoma, melanoma, and conventional glioblastoma multiforme having the greatest prevalence of alterations [3].

MET GENIE Cases - Top Diseases

The most common alterations in MET are MET Mutation (2.53%), MET Amplification (0.71%), MET Exon 14 Mutation (0.26%), MET c.1078-c.1345 Missense (0.15%), and MET D1010H (0.06%) [3].

MET GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of MET in Diseases

Non-Small Cell Lung Carcinoma +

Malignant Solid Tumor +

Breast Carcinoma +

Colorectal Carcinoma +

Hepatocellular Carcinoma +

Melanoma +

Gastric Adenocarcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Head And Neck Squamous Cell Carcinoma +

Squamous Cell Lung Carcinoma +

Cancer +

Glioblastoma +

Renal Cell Carcinoma +

Gastric Carcinoma +

Endometrial Carcinoma +

Non-Hodgkin Lymphoma +

Urothelial Carcinoma +

Bladder Carcinoma +

Lymphoma +

Ovarian Carcinoma +

Pancreatic Carcinoma +

Head And Neck Carcinoma +

Esophageal Carcinoma +

Colorectal Adenocarcinoma +

Prostate Carcinoma +

Pancreatic Adenocarcinoma +

Ewing Sarcoma +

Multiple Myeloma +

Osteosarcoma +

Papillary Renal Cell Carcinoma +

Malignant Uterine Neoplasm +

Undifferentiated Pleomorphic Sarcoma +

Lung Carcinoma +

Small Cell Lung Carcinoma +

Anaplastic Astrocytoma +

Glioma +

B-Cell Non-Hodgkin Lymphoma +

Soft Tissue Sarcoma +

Cervical Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Mesothelioma +

Sarcoma +

Thyroid Gland Carcinoma +

Bile Duct Carcinoma +

Cholangiocarcinoma +

Adrenal Cortex Carcinoma +

Aggressive Systemic Mastocytosis +

Alveolar Soft Part Sarcoma +

Bronchogenic Carcinoma +

Cervical Squamous Cell Carcinoma +

Chondrosarcoma +

Classical Hodgkin Lymphoma +

Clear Cell Sarcoma Of Soft Tissue +

Desmoid-Type Fibromatosis +

Diffuse Intrinsic Pontine Glioma +

Esophageal Squamous Cell Carcinoma +

Gallbladder Carcinoma +

Gliosarcoma +

Hematologic And Lymphocytic Disorder +

Hematopoietic And Lymphoid Malignancy +

Hematopoietic And Lymphoid System Neoplasm +

Hepatoblastoma +

Histiocytic And Dendritic Cell Neoplasm +

Liposarcoma +

Mast Cell Leukemia +

Medulloblastoma +

Myelodysplastic Syndromes +

Myeloid Neoplasm +

Oropharyngeal Squamous Cell Carcinoma +

Pecoma +

Peritoneal Mesothelioma +

Rhabdomyosarcoma +

Small Intestinal Adenocarcinoma +

Systemic Mastocytosis With An Associated Hematological Neoplasm (SM-AHN) +

Thyroid Gland Medullary Carcinoma +

Wilms Tumor +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.