Overview

Location [1]
10q11.21
Pathways
Receptor tyrosine kinase/growth factor signaling, Kinase fusions
Protein [2]
Extracellular cell-membrane anchored RET cadherin 120 kDa fragment
Synonyms [1]
MTC1, PTC, CDHF12, MEN2B, RET51, CDHR16, HSCR1, MEN2A, RET-ELE1

The RET gene (ret proto-oncogene), encodes the proto-oncogene tyrosine-protein kinase receptor Ret, a receptor tyrosine kinase (RTK). Activating point mutations in RET can give rise to the hereditary cancer syndrome, multiple endocrine neoplasia 2 (MEN2; PMID: 11061555). Activating somatic point mutations in RET are associated with sporadic medullary thyroid cancer (PMID: 16946010; PMID: 11061555). Oncogenic kinase fusions involving the RET gene are found in non-small cell lung cancers (PMID: 22395697).

 

RET is altered in 2.53% of all cancers with non-small cell lung carcinoma, colorectal adenocarcinoma, melanoma, thyroid gland neoplasm, and breast carcinoma having the greatest prevalence of alterations [3].

RET GENIE Cases - Top Diseases

The most common alterations in RET are RET Mutation (2.78%), RET Loss (0.18%), RET M918T (0.13%), RET Amplification (0.08%), and RET D567N (0.03%) [3].

RET GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of RET in Diseases

Non-Small Cell Lung Carcinoma +

Thyroid Gland Medullary Carcinoma +

Malignant Solid Tumor +

Multiple Myeloma +

Thyroid Gland Carcinoma +

Melanoma +

Pancreatic Carcinoma +

Endometrial Carcinoma +

Gastric Carcinoma +

Squamous Cell Lung Carcinoma +

Lung Carcinoma +

Non-Hodgkin Lymphoma +

Head And Neck Squamous Cell Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Urothelial Carcinoma +

Lung Adenocarcinoma +

Ovarian Carcinoma +

Colorectal Carcinoma +

Esophageal Carcinoma +

Lymphoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Thyroid Gland Papillary Carcinoma +

Renal Cell Carcinoma +

Breast Carcinoma +

Gastrointestinal Stromal Tumor +

Cancer +

Hepatobiliary Neoplasm +

Lip And Oral Cavity Carcinoma +

Malignant Central Nervous System Neoplasm +

Malignant Laryngeal Neoplasm +

Malignant Salivary Gland Neoplasm +

Nasal Cavity And Paranasal Sinus Carcinoma +

Nasopharyngeal Carcinoma +

Oropharyngeal Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.