Associated Genetic Biomarkers
Associated Diseases
Associated Pathways

Overview

Location [1]
10q11.21
Pathways
Kinase fusions, Receptor tyrosine kinase/growth factor signaling
Synonyms [1]
MEN2B, MEN2A, PTC, CDHR16, RET-ELE1, HSCR1, CDHF12, MTC1

The RET gene (ret proto-oncogene), encodes the proto-oncogene tyrosine-protein kinase receptor Ret, a receptor tyrosine kinase (RTK). Activating point mutations in RET can give rise to the hereditary cancer syndrome, multiple endocrine neoplasia 2 (MEN2; PMID: 11061555). Activating somatic point mutations in RET are associated with sporadic medullary thyroid cancer (PMID: 16946010; PMID: 11061555). Oncogenic kinase fusions involving the RET gene are found in non-small cell lung cancers (PMID: 22395697).

 

Biomarker-Directed Therapies

Significance of RET in Diseases

Non-Small Cell Lung Carcinoma +

Thyroid Gland Medullary Carcinoma +

Thyroid Gland Carcinoma +

Malignant Solid Tumor +

Melanoma +

Breast Carcinoma +

Colorectal Carcinoma +

Non-Squamous Non-Small Cell Lung Carcinoma +

Pancreatic Carcinoma +

Renal Cell Carcinoma +

Squamous Cell Lung Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Bladder Carcinoma +

Endometrial Carcinoma +

Head And Neck Carcinoma +

Hepatocellular Carcinoma +

Lung Carcinoma +

Lymphoma +

Multiple Myeloma +

Ovarian Carcinoma +

Poorly Differentiated Thyroid Gland Carcinoma +

Prostate Carcinoma +

Soft Tissue Sarcoma +

Thyroid Gland Papillary Carcinoma +

Urothelial Carcinoma +

Acute Lymphoblastic Leukemia +

Acute Myeloid Leukemia +

Adrenal Cortex Carcinoma +

Adrenal Gland Pheochromocytoma +

Alveolar Soft Part Sarcoma +

B-Cell Non-Hodgkin Lymphoma +

Bile Duct Carcinoma +

Bronchogenic Carcinoma +

Cancer +

Cervical Carcinoma +

Cervical Squamous Cell Carcinoma +

Chronic Myeloid Leukemia +

Clear Cell Sarcoma Of Soft Tissue +

Esophageal Carcinoma +

Esophageal Squamous Cell Carcinoma +

Ewing Sarcoma +

Gallbladder Carcinoma +

Gastric Adenocarcinoma +

Gastric Carcinoma +

Gastrointestinal Stromal Tumor +

Head And Neck Squamous Cell Carcinoma +

Hepatobiliary Neoplasm +

Hepatoblastoma +

High Grade Ovarian Serous Adenocarcinoma +

Histiocytosis +

Leukemia +

Lip And Oral Cavity Carcinoma +

Lung Adenocarcinoma +

Malignant Central Nervous System Neoplasm +

Malignant Hepatobiliary Neoplasm +

Malignant Laryngeal Neoplasm +

Malignant Salivary Gland Neoplasm +

Malignant Uterine Neoplasm +

Mesothelioma +

Nasal Cavity And Paranasal Sinus Carcinoma +

Nasopharyngeal Carcinoma +

Neuroendocrine Carcinoma +

Non-Hodgkin Lymphoma +

Oropharyngeal Carcinoma +

Osteosarcoma +

Pancreatic Adenocarcinoma +

Rhabdomyosarcoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

Wilms Tumor +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.