Biomarkers /
ROS1
Overview
ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase) is a gene that encodes the proto-oncogene tyrosine-protein kinase ROS protein, a receptor tyrosine kinase (RTK) of the insulin receptor family. ROS1 fusions have been described in glioblastoma (PMID: 2827175; PMID: 2352949; PMID: 12661006), non-small cell lung cancer (PMID: 18083107), and cholangiocarcinoma (PMID: 21253578). ROS1 fusions containing an intact tyrosine kinase domain possess oncogenic activity (PMID: 12661006; PMID: 18083107). Signaling downstream of ROS1 fusions results in activation of cellular pathways known to be involved in cell growth and cell proliferation.
Biomarker-Directed Therapies
Clinical Trials
Significance of ROS1 in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.