Overview

Location [1]
6q22.1
Pathways
Kinase fusions, Receptor tyrosine kinase/growth factor signaling
Synonyms [1]
ROS, MCF3, c-ros-1

ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase) is a gene that encodes the proto-oncogene tyrosine-protein kinase ROS protein, a receptor tyrosine kinase (RTK) of the insulin receptor family. ROS1 fusions have been described in glioblastoma (PMID: 2827175; PMID: 2352949; PMID: 12661006), non-small cell lung cancer (PMID: 18083107), and cholangiocarcinoma (PMID: 21253578). ROS1 fusions containing an intact tyrosine kinase domain possess oncogenic activity (PMID: 12661006PMID: 18083107). Signaling downstream of ROS1 fusions results in activation of cellular pathways known to be involved in cell growth and cell proliferation.

Biomarker-Directed Therapies

Significance of ROS1 in Diseases

Non-Small Cell Lung Carcinoma +

Malignant Solid Tumor +

Colorectal Carcinoma +

Melanoma +

Cancer +

Anaplastic Large Cell Lymphoma +

Bladder Carcinoma +

Breast Carcinoma +

Head And Neck Carcinoma +

Lung Carcinoma +

Non-Hodgkin Lymphoma +

Prostate Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

B-Cell Non-Hodgkin Lymphoma +

Bile Duct Carcinoma +

Bronchogenic Carcinoma +

Cervical Carcinoma +

Cervical Squamous Cell Carcinoma +

Endometrial Carcinoma +

Esophageal Squamous Cell Carcinoma +

Gallbladder Carcinoma +

Gastric Adenocarcinoma +

Hepatocellular Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Lung Adenocarcinoma +

Malignant Central Nervous System Neoplasm +

Malignant Uterine Neoplasm +

Mesothelioma +

Mucosal Melanoma +

Multiple Myeloma +

Non-Squamous Non-Small Cell Lung Carcinoma +

Ovarian Carcinoma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Renal Cell Carcinoma +

Soft Tissue Sarcoma +

Squamous Cell Lung Carcinoma +

Urothelial Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.