Overview

Location [1]
19p13.3
Synonyms [1]
hLKB1, PJS, LKB1

Serine/threonine kinase 11 (STK11) is a gene that encodes a protein that belongs to the serine/threonine kinase family. The protein functions in the regulation of cell polarity and is also a tumor suppressor. Missense mutations, nonsense mutations, silent mutations, whole gene deletions, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as cervical cancer, gastrointestinal cancer, and lung cancer.

Significance of STK11 in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Non-Small Cell Lung Carcinoma +

Prostate Carcinoma +

Breast Carcinoma +

Ovarian Carcinoma +

Colorectal Carcinoma +

Cervical Carcinoma +

Endometrial Carcinoma +

Primary Peritoneal Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Fallopian Tube Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Non-Hodgkin Lymphoma +

Pancreatic Carcinoma +

Urothelial Carcinoma +

Ampulla Of Vater Carcinoma +

Anal Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Bladder Carcinoma +

Bladder Urothelial Carcinoma +

Cancer +

Cholangiocarcinoma +

Diffuse Large B-Cell Lymphoma +

Esophageal Carcinoma +

Gastric Carcinoma +

Gastrointestinal Stromal Tumor +

High Grade Ovarian Serous Adenocarcinoma +

Lung Adenocarcinoma +

Malignant Esophagogastric Neoplasm +

Malignant Gastric Neoplasm +

Malignant Intestinal Neoplasm +

Malignant Ovarian Epithelial Tumor +

Malignant Small Intestinal Neoplasm +

Mantle Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Melanoma +

Multiple Myeloma +

Pancreatic Adenocarcinoma +

Penile Carcinoma +

Renal Cell Carcinoma +

Small Cell Lung Carcinoma +

Soft Tissue Sarcoma +

Squamous Cell Lung Carcinoma +

Thyroid Gland Carcinoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.