Overview

Location [1]
19p13.3
Protein [2]
Serine/threonine-protein kinase STK11
Synonyms [1]
PJS, LKB1, hLKB1

Serine/threonine kinase 11 (STK11) is a gene that encodes a protein that belongs to the serine/threonine kinase family. The protein functions in the regulation of cell polarity and is also a tumor suppressor. Missense mutations, nonsense mutations, silent mutations, whole gene deletions, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as cervical cancer, gastrointestinal cancer, and lung cancer.

STK11 is altered in 2.56% of all cancers with lung adenocarcinoma, breast invasive ductal carcinoma, colon adenocarcinoma, non-small cell lung carcinoma, and adenocarcinoma of unknown primary having the greatest prevalence of alterations [3].

STK11 GENIE Cases - Top Diseases

The most common alterations in STK11 are STK11 Mutation (3.46%), STK11 Loss (0.29%), STK11 P281Rfs*6 (0.15%), STK11 S216F (0.08%), and STK11 Amplification (0.06%) [3].

STK11 GENIE Cases - Top Alterations

Significance of STK11 in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Prostate Carcinoma +

Non-Small Cell Lung Carcinoma +

Ovarian Carcinoma +

Breast Carcinoma +

Primary Peritoneal Carcinoma +

Cervical Carcinoma +

Endometrial Carcinoma +

Urothelial Carcinoma +

Colorectal Carcinoma +

Non-Hodgkin Lymphoma +

Fallopian Tube Carcinoma +

Cholangiocarcinoma +

Pancreatic Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Lung Adenocarcinoma +

Anal Carcinoma +

Cancer +

Squamous Cell Lung Carcinoma +

Bladder Urothelial Carcinoma +

Bladder Carcinoma +

Malignant Esophagogastric Neoplasm +

Melanoma +

Pancreatic Adenocarcinoma +

Esophageal Carcinoma +

Malignant Intestinal Neoplasm +

Thyroid Gland Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Malignant Ovarian Epithelial Tumor +

Gastric Carcinoma +

Malignant Gastric Neoplasm +

Soft Tissue Sarcoma +

Renal Cell Carcinoma +

Kidney Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Ampulla Of Vater Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Clear Cell Renal Cell Carcinoma +

Diffuse Large B-Cell Lymphoma +

Gastrointestinal Stromal Tumor +

Hepatocellular Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Malignant Small Intestinal Neoplasm +

Mantle Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mesothelioma +

Multiple Myeloma +

Penile Carcinoma +

Small Cell Lung Carcinoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.