Overview

Gene Location [1]
2p23.2-p23.1
Pathways
Kinase fusions, Receptor tyrosine kinase/growth factor signaling
Variant Type
Fusion
Gene
ALK

Biomarker-Directed Therapies

Significance of ALK Fusion in Diseases

Non-Small Cell Lung Carcinoma +

Inflammatory Myofibroblastic Tumor +

Malignant Solid Tumor +

Anaplastic Large Cell Lymphoma +

Cancer +

Non-Hodgkin Lymphoma +

B-Cell Non-Hodgkin Lymphoma +

Diffuse Large B-Cell Lymphoma +

Diffuse Large B-Cell Lymphoma, Not Otherwise Specified +

Lymphoma +

T-Cell/Histiocyte-Rich Large B-Cell Lymphoma +

B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma +

Double-Hit Lymphoma +

Mantle Cell Lymphoma +

Mediastinal Large B-Cell Lymphoma +

Multiple Myeloma +

Neuroblastoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Anaplastic Large Cell Lymphoma, ALK-Positive +

Burkitt Lymphoma +

Colorectal Carcinoma +

Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation +

Follicular Lymphoma +

Gastric Carcinoma +

Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma +

High Grade B-Cell Lymphoma, Not Otherwise Specified +

Intravascular Large B-Cell Lymphoma +

Lymphomatoid Granulomatosis +

Melanoma +

Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type +

Transformed Lymphoma +

ALK-Positive Large B-Cell Lymphoma +

Angioimmunoblastic T-Cell Lymphoma +

Breast Carcinoma +

Central Nervous System Neoplasm +

Cholangiocarcinoma +

Enteropathy-Associated T-Cell Lymphoma +

Esophageal Carcinoma +

Extranodal Marginal Zone Lymphoma Of Mucosa-Associated Lymphoid Tissue +

Glioblastoma +

Grade 3b Follicular Lymphoma +

Hepatocellular Carcinoma +

Hepatosplenic T-Cell Lymphoma +

Histiocytic And Dendritic Cell Neoplasm +

Hodgkin Lymphoma +

Lung Carcinoma +

Lymphoblastic Lymphoma +

Malignant Neoplasm +

Mature B-Cell Lymphoma/Leukemia +

Mature B-Cell Non-Hodgkin Lymphoma +

Mature T-Cell And NK-Cell Lymphoma/Leukemia +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mycosis Fungoides +

Nodal Marginal Zone Lymphoma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Peripheral T-Cell Lymphoma, NOS +

Primary Central Nervous System Lymphoma +

Primary Effusion Lymphoma +

Sezary Syndrome +

Small Intestinal Carcinoma +

Splenic Marginal Zone Lymphoma +

Thyroid Gland Carcinoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

Triple-Hit Lymphoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.