Associated Genetic Biomarkers
FANCL Loss is a predictive biomarker for use of olaparib in patients.
Of the therapies with FANCL Loss as a predictive biomarker, 1 is FDA-approved and 1 has NCCN guidelines in at least one clinical setting.
Prostate carcinoma has the most therapies targeted against FANCL Loss or its related pathways .
Prostate Carcinoma -
Sample must match one or more of the following:
ATM Mutation, BRCA1 Mutation, BRCA2 Mutation, FANCL Mutation, PALB2 Mutation, ATM Loss, BARD1 Loss, BARD1 Mutation, BRCA1 Loss, BRCA2 Loss, BRIP1 Loss, BRIP1 Mutation, CDK12 Loss, CDK12 Mutation, CHEK1 Loss, CHEK1 Mutation, CHEK2 Loss, CHEK2 Mutation, FANCL Loss, PALB2 Loss, RAD51B Loss, RAD51B Mutation, RAD51C Loss, RAD51C Mutation, RAD51D Loss, RAD51D Mutation, RAD54L Loss, RAD54L Mutation
|Predicted Response: Primary Sensitivity|
|Clinical Setting(s): Metastatic (FDA, NCCN)|
|Note: Approved for adult patients with deleterious or suspected deleterious germline or somatic homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer (mCRPC), who have progressed following prior treatment with enzalutamide or abiraterone.|
Significance of FANCL Loss in Diseases
Prostate Carcinoma +
Olaparib has evidence of efficacy in patients with FANCL Loss in prostate carcinoma .
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Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.
4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.