Associated Diseases


Biomarker-Directed Therapies

Significance of HER2 Positive in Diseases

Breast Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Gastric Adenocarcinoma +

Gastric Carcinoma +

Colorectal Carcinoma +

Esophageal Carcinoma +

Malignant Salivary Gland Neoplasm +

Endometrial Adenocarcinoma +

Malignant Esophageal Neoplasm +

Malignant Solid Tumor +

Invasive Breast Carcinoma +

Non-Small Cell Lung Carcinoma +

Endometrial Carcinoma +

Esophageal Adenocarcinoma +

Breast Adenocarcinoma +

Ovarian Carcinoma +

Urothelial Carcinoma +

Ductal Carcinoma In Situ +

Head And Neck Squamous Cell Carcinoma +

Inflammatory Breast Carcinoma +

Melanoma +

Pancreatic Carcinoma +

Biliary Tract Carcinoma +

Cervical Carcinoma +

Gallbladder Carcinoma +

Non-Squamous Non-Small Cell Lung Carcinoma +

Bile Duct Carcinoma +

Bladder Carcinoma +

Cancer +

Colorectal Adenocarcinoma +

Hepatocellular Carcinoma +

Prostate Carcinoma +

Cholangiocarcinoma +

Esophageal Squamous Cell Carcinoma +

Head And Neck Carcinoma +

Leukemia +

Lung Adenocarcinoma +

Lung Carcinoma +

Lymphoma +

Malignant Uterine Neoplasm +

Renal Cell Carcinoma +

Ampulla Of Vater Carcinoma +

Biliary Tract Neoplasm +

Breast Invasive Ductal Carcinoma +

Bronchogenic Carcinoma +

Carcinoma +

Central Nervous System Neoplasm +

Digestive System Carcinoma +

Endometrial Serous Adenocarcinoma +

Ependymoma +

Extrahepatic Cholangiocarcinoma +

Germ Cell Tumor +

Glioblastoma +

Glioma +

Gliosarcoma +

Hypopharyngeal Squamous Cell Carcinoma +

Intrahepatic Cholangiocarcinoma +

Laryngeal Squamous Cell Carcinoma +

Liposarcoma +

Low Grade Glioma +

Malignant Bone Marrow Neoplasm +

Malignant Central Nervous System Neoplasm +

Malignant Colorectal Neoplasm +

Malignant Digestive System Neoplasm +

Malignant Endometrial Neoplasm +

Malignant Glioma +

Malignant Ovarian Epithelial Tumor +

Malignant Ovarian Neoplasm +

Malignant Urethral Neoplasm +

Medulloblastoma +

Metastatic Malignant Neoplasm In The Brain +

Oral Cavity Squamous Cell Carcinoma +

Oropharyngeal Squamous Cell Carcinoma +

Osteosarcoma +

Prostate Adenocarcinoma +

Salivary Carcinoma, NOS +

Salivary Duct Carcinoma +

Salivary Gland Acinic Cell Carcinoma +

Salivary Gland Adenocarcinoma +

Salivary Gland Carcinoma +

Salivary Gland Carcinoma Ex Pleomorphic Adenoma +

Salivary Gland Mucoepidermoid Carcinoma +

Salivary Gland Small Cell Carcinoma +

Salivary Gland Squamous Cell Carcinoma +

Sarcoma +

Small Cell Lung Carcinoma +

Small Intestinal Carcinoma +

Soft Tissue Sarcoma +

Squamous Cell Lung Carcinoma +

Uterine Carcinosarcoma +

Uterine Corpus Carcinosarcoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.