Associated Genetic Biomarkers

Overview

Gene Location [1]
15q15.1
Pathway
DNA damage/repair
Variant Type
Loss
Gene
RAD51

RAD51 Loss is present in 0.16% of AACR GENIE cases, with diffuse large B-cell lymphoma, not otherwise specified, acral lentiginous melanoma, cutaneous melanoma, high grade ovarian serous adenocarcinoma, and invasive breast carcinoma having the greatest prevalence [4].

Top Disease Cases with RAD51 Loss

Significance of RAD51 Loss in Diseases

Malignant Solid Tumor +

Breast Carcinoma +

Ovarian Carcinoma +

Prostate Adenocarcinoma +

Prostate Carcinoma +

Primary Peritoneal Carcinoma +

Fallopian Tube Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Non-Small Cell Lung Carcinoma +

Pancreatic Adenocarcinoma +

Small Cell Lung Carcinoma +

Endometrial Carcinoma +

Gastric Adenocarcinoma +

Soft Tissue Sarcoma +

Gastrointestinal Stromal Tumor +

Clear Cell Renal Cell Carcinoma +

Esophageal Adenocarcinoma +

Esophageal Carcinoma +

Gastric Carcinoma +

Head And Neck Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Osteosarcoma +

Squamous Cell Lung Carcinoma +

Urothelial Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Non-Hodgkin Lymphoma +

Melanoma +

Rhabdomyosarcoma +

Leiomyosarcoma +

Neuroblastoma +

High Grade Ovarian Serous Adenocarcinoma +

Malignant Ovarian Epithelial Tumor +

Colorectal Adenocarcinoma +

Colorectal Carcinoma +

Malignant Intestinal Neoplasm +

Ampulla Of Vater Carcinoma +

Bile Duct Adenocarcinoma +

Biliary Tract Carcinoma +

Bladder Urothelial Carcinoma +

Cervical Carcinoma +

Ewing Sarcoma +

Low Grade Ovarian Serous Adenocarcinoma +

Malignant Esophagogastric Neoplasm +

Malignant Gastric Neoplasm +

Malignant Mesothelioma +

Malignant Small Intestinal Neoplasm +

Multiple Myeloma +

Ovarian Clear Cell Adenocarcinoma +

Pancreatic Carcinoma +

Pancreatic Ductal Adenocarcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.