Overview

NCI Definition: A myelodysplastic/myeloproliferative neoplasm characterized by the principal involvement of the neutrophil series with leukocytosis and multilineage dysplasia. The neoplastic cells do not have a Philadelphia chromosome or the BCR/ABL fusion gene. (WHO, 2001) [1]

Significant Genes in Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative

AFF1 +

CBFB +

CSF3R +

ELL +

IDH1 +

IDH2 +

KMT2A +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MYH11 +

NPM1 +

NRIP3 +

PML +

RARA +

RPN1 +

RUNX1 +

RUNX1T1 +

Disease Details

Synonyms
Subacute Myelogenous Leukemia, Subacute Myeloid Leukemia, Atypical Chronic Myeloid Leukemia, Subacute Granulocytic Leukemia, Atypical CML, aCML
Parent(s)
Myelodysplastic/Myeloproliferative Neoplasm
OncoTree Name
Atypical Chronic Myeloid Leukemia, BCR-ABL1-
OncoTree Code
ACML

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.